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Diagnostic implication of fibrin degradation products and D-dimer in aortic dissection

Jian Dong1, Xianli Duan1, Rui Feng1

  • 1Department of Vascular Surgery, Changhai Hospital, Second Military Medical University, Shanghai 200433, China.

Scientific Reports
|March 7, 2017
PubMed

Insights

Fibrin degradation products (FDP) and D-dimer are elevated in aortic dissection patients. While not highly specific for differentiating from other cardiovascular diseases, they show diagnostic value against healthy controls.

Area of Science:

  • Vascular Medicine
  • Diagnostic Biomarkers
  • Cardiovascular Diseases

Background:

  • Fibrin degradation products (FDP) and D-dimer are implicated in vascular diseases.
  • Their diagnostic utility in aortic dissection requires further clarification.

Purpose of the Study:

  • To investigate the diagnostic value of FDP and D-dimer in patients with aortic dissection.
  • To compare FDP and D-dimer levels in aortic dissection patients versus other cardiovascular conditions and healthy individuals.

Main Methods:

  • Immune nephelometry was used to measure FDP and D-dimer levels.
  • Logistic regression analysis assessed risk factors for aortic dissection.
  • Receiver Operating Characteristic (ROC) curve analysis determined diagnostic accuracy.

Main Results:

  • Aortic dissection patients exhibited significantly higher FDP and D-dimer levels compared to non-dissection patients and healthy controls.
  • Both FDP and D-dimer were identified as risk factors for aortic dissection.
  • ROC analysis indicated limited ability to distinguish aortic dissection from other cardiovascular diseases, but significant value (AUC 0.863) in differentiating from healthy controls.

Conclusions:

  • Elevated FDP and D-dimer levels are associated with aortic dissection.
  • FDP and D-dimer show potential as biomarkers for distinguishing aortic dissection from healthy states, but lack specificity for differentiating from other cardiovascular diseases.

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