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Updated: Mar 6, 2026

MALDI Imaging Mass Spectrometry of Neuropeptides in Parkinson's Disease
Published on: February 14, 2012
[Dyskinesia in Parkinson's disease: an update on new neuroimaging methods and treatment possibilities]
Birgitte Liang Chen Thomsen1, Damian Marc Herz, Hartwig Roman Siebner
1annemette.loekkegaard@regionh.dk.
Abstract:
Levodopa-induced dyskinesia (LID) represents a severe adverse effect of long-term treatment of Parkinson's disease with levodopa. Neuroimaging studies have contributed to our understanding of LID and may help to identify patients at risk of developing LID. Amantadine can be used for the treatment of LID, and novel drugs are under development. Deep brain stimulation of the subthalamic nucleus and globus pallidus internus alleviates LID, the former indirectly by reducing levodopa intake, the latter through direct effects. Repetitive transcranial magnetic stimulation has been shown to transiently improve LID.
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