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Author Spotlight: Noninvasive Cerebral Blood Flow Determination in Human Functional Brain Region for Diagnosis of Neurological Disorders
Published on: May 31, 2024
Regional Cerebral Blood Flow SPECT and MRI in Logopenic Variant Primary Progressive Aphasia
Aristeidis H Katsanos1, Spyridon Tsiouris, Chrissa Sioka
1From the *Department of Neurology, †Department of Nuclear Medicine, ‡Neurosurgical Research Institute, School of Medicine, and §Department of Radiology, Medical School, University of Ioannina, Ioannina, Greece.
Abstract:
We report a 61-year-old woman who presented because of gradually progressive speech disorders. MRI scan revealed left temporal lobe atrophy with ex vacuo dilatation of the temporal horn and atrophy of the left inferior frontal gyrus and the left inferior parietal lobe. These findings in brain perfusion SPECT corresponded to a generalized hypoperfusion of the left hemisphere, particularly prominent on the rear parietal cortex and the temporal lobe. After taking into consideration the clinical presentation and imaging findings on MRI and SPECT, the diagnosis of the logopenic variant of primary progressive aphasia was finally reached.
