Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Immunodeficiency Diseases01:25

Immunodeficiency Diseases

2.7K
Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...
2.7K
Development of Immunocompetence01:22

Development of Immunocompetence

1.1K
The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
1.1K
Antigens Involved in Adaptive Immunity01:26

Antigens Involved in Adaptive Immunity

1.7K
An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and...
1.7K
Special Features of Adaptive Immunity01:20

Special Features of Adaptive Immunity

3.8K
The adaptive immune system, a crucial component of the overall immune response, offers a highly specialized defense against pathogens. It involves specific cell types and features, enabling it to combat infections effectively and efficiently.
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...
3.8K
Factors Affecting the Risk of Infection01:26

Factors Affecting the Risk of Infection

14.3K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
14.3K
Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

85.4K
Overview
85.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Immunological spectrum in patients with thymoma: beyond good syndrome.

Immunologic research·2026
Same author

Primary immunodeficiencies: Clinical spectrum and follow-up challenges.

Allergologia et immunopathologia·2026
Same author

Morning Versus Evening Administration of Intranasal Mometasone Furoate in Seasonal Allergic Rhinitis: A Baseline-Adjusted Comparative Study.

Ear, nose, & throat journal·2026
Same author

Can food allergy trigger acute pancreatitis? Exploring an unusual etiology.

Allergologia et immunopathologia·2026
Same author

Pregnancy and lactation in patients with common variable immunodeficiency: a single center experience.

Allergologia et immunopathologia·2026
Same author

Adverse reactions to intravenous immunoglobulin in primary immunodeficiency: a retrospective analysis.

Postepy dermatologii i alergologii·2026

Related Experiment Video

Updated: Mar 6, 2026

Author Spotlight: Advancing Immune Monitoring in Critical Care Patients Using Whole Blood Assays
06:03

Author Spotlight: Advancing Immune Monitoring in Critical Care Patients Using Whole Blood Assays

Published on: September 20, 2024

1.9K

Adults with common variable immunodeficiency: a single-center experience.

Uğur Haci Muşabak1, Fevzi Demirel2, Sait Yeşillik2

  • 1Division of Immunology and Allergic Diseases, Lösante Hospital, Ankara, Turkey.

Turkish Journal of Medical Sciences
|March 7, 2017
PubMed
Summary
This summary is machine-generated.

Common variable immunodeficiency (CVID) in adults presents with frequent clinical signs like infections and low body weight. A low CD4/CD8 ratio is linked to reduced antibody production and immune activation in CVID patients.

More Related Videos

Development of an IFN-γ ELISpot Assay to Assess Varicella-Zoster Virus-specific Cell-mediated Immunity Following Umbilical Cord Blood Transplantation
08:04

Development of an IFN-γ ELISpot Assay to Assess Varicella-Zoster Virus-specific Cell-mediated Immunity Following Umbilical Cord Blood Transplantation

Published on: July 9, 2014

16.4K
Simultaneous Quantification of T-Cell Receptor Excision Circles TRECs and K-Deleting Recombination Excision Circles KRECs by Real-time PCR
14:14

Simultaneous Quantification of T-Cell Receptor Excision Circles TRECs and K-Deleting Recombination Excision Circles KRECs by Real-time PCR

Published on: December 6, 2014

17.4K

Related Experiment Videos

Last Updated: Mar 6, 2026

Author Spotlight: Advancing Immune Monitoring in Critical Care Patients Using Whole Blood Assays
06:03

Author Spotlight: Advancing Immune Monitoring in Critical Care Patients Using Whole Blood Assays

Published on: September 20, 2024

1.9K
Development of an IFN-γ ELISpot Assay to Assess Varicella-Zoster Virus-specific Cell-mediated Immunity Following Umbilical Cord Blood Transplantation
08:04

Development of an IFN-γ ELISpot Assay to Assess Varicella-Zoster Virus-specific Cell-mediated Immunity Following Umbilical Cord Blood Transplantation

Published on: July 9, 2014

16.4K
Simultaneous Quantification of T-Cell Receptor Excision Circles TRECs and K-Deleting Recombination Excision Circles KRECs by Real-time PCR
14:14

Simultaneous Quantification of T-Cell Receptor Excision Circles TRECs and K-Deleting Recombination Excision Circles KRECs by Real-time PCR

Published on: December 6, 2014

17.4K

Area of Science:

  • Immunology
  • Clinical Medicine

Background:

  • Common variable immunodeficiency (CVID) is a primary immunodeficiency characterized by impaired antibody production.
  • Adult CVID patients often exhibit a range of clinical manifestations and immunological abnormalities.

Purpose of the Study:

  • To investigate the clinical and immunological characteristics of adult patients diagnosed with CVID.
  • To identify correlations between clinical signs, histological findings, and immunophenotypic parameters in CVID.

Main Methods:

  • Retrospective analysis of clinical and laboratory data from 31 adult CVID patients.
  • Classification of patients into clinical and immunophenotypic subgroups for comparative analysis.
  • Statistical analysis to determine significant associations between variables.

Main Results:

  • Frequent clinical signs included low body weight (45.2%), urinary tract infections (41.9%), dermatoses (35.5%), and oral aphthae (32.3%).
  • Gastrointestinal histological findings (nodular lymphoid hyperplasia, villous atrophy, lymphocytic infiltrates) correlated with splenomegaly, hepatomegaly, and low body weight (P < 0.05).
  • Low CD4/CD8 ratios were associated with decreased IgG levels, reduced CD19+ B cell percentage, and increased activated T cells (P < 0.05).

Conclusions:

  • Certain clinical signs occur frequently in adult CVID but may be underreported.
  • The CD4/CD8 ratio is a significant factor influencing antibody production and clinical presentation in CVID.
  • Evidence suggests ongoing subclinical immune activation in the adaptive immune system of CVID patients.