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Response to Comment on "Assessing Aromatic-Hydrocarbon Toxicity to Fish Early Life Stages Using Passive-Dosing

Josh D Butler1, Thomas F Parkerton2, Aaron D Redman1

  • 1Toxicology & Environmental Sciences Division, ExxonMobil Biomedical Sciences, Inc. 1545 US Highway 22 East, Annandale, New Jersey 08801-3059, United States.

Environmental Science & Technology
|March 7, 2017
PubMed
Abstract

No abstract available in PubMed .

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Toxicity tests in animals are grounded on two main assumptions: first, the effects observed in laboratory animals can be extrapolated to humans, especially when adjusted for body surface area; second, high-dose exposure in animals is essential to identify potential human hazards from lower doses. This is based on the quantal dose-response concept, which faces the challenge of extrapolating results from relatively few test animals to much larger human populations. For example, a 0.01% incidence...
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