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Related Concept Videos

Insulin Formulations: Types and Delivery01:27

Insulin Formulations: Types and Delivery

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Insulin preparations are categorized by their duration of action into short-acting and long-acting types. Two strategies are used to modify insulin's absorption and pharmacokinetic profile: slowing the absorption post-subcutaneous injection, or altering human insulin's amino acid sequence or protein structure. These changes retain the insulin's ability to bind to the insulin receptor, but alter its behavior in solution or after injection.
Short-acting insulins are divided into...
901
Insulin: Dosing Regimen and Adverse Effects01:16

Insulin: Dosing Regimen and Adverse Effects

991
Insulin-replacement therapy usually includes both long-acting insulin (basal) and short-acting insulin (to cater to postprandial needs). In a diverse group of type 1 diabetes patients, the average daily insulin dose is typically 0.5-0.7 units/kg body weight. However, obese patients and pubertal adolescents may need more due to insulin resistance.
The basal dose constitutes about 40%-50% of the total daily dose, with the rest as premeal insulin. The mealtime insulin dose should mirror...
991
Parenteral Drug Delivery Systems: Injectables, Implants, and Infusion Devices01:28

Parenteral Drug Delivery Systems: Injectables, Implants, and Infusion Devices

67
Parenteral drug delivery systems play a crucial role in modern therapeutics by enabling the direct administration of drugs into the systemic circulation, bypassing the gastrointestinal tract. These systems are particularly valuable for poorly absorbed oral medications that are unstable in the digestive environment or require rapid onset or sustained therapeutic levels. Delivery is achieved through intravenous, intramuscular, or subcutaneous routes, each selected based on the drug's properties...
67
Inhaled Medications01:23

Inhaled Medications

929
Inhaled medications are crucial for managing chronic obstructive pulmonary disease (COPD) and asthma. They are essential for effective treatment and control, ensuring optimal respiratory health and well-being. Inhaled medication delivers drugs directly to the lungs, providing a rapid onset of action and reducing systemic side effects compared to oral or injectable medications. Three primary types of inhalation devices are used to administer these medications: nebulizers, metered-dose inhalers...
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Drug Delivery: Parenteral Route01:29

Drug Delivery: Parenteral Route

2.0K
The parenteral route is a critical method of drug administration. It delivers compounds directly into the systemic circulation and bypasses the gastrointestinal tract. This approach is particularly advantageous for drugs that exhibit poor absorption or instability when administered orally.
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
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Oral Hypoglycemic Agents: Glinides01:06

Oral Hypoglycemic Agents: Glinides

780
Repaglinide (Prandin) and Nateglinide (Starlix), known as glinides, are oral insulin secretagogues that stimulate insulin release from pancreatic β cells by closing the ATP-sensitive potassium channels (KATP channel). Repaglinide controls insulin release from pancreatic β cells by managing potassium efflux. It shares two binding sites with sulfonylureas and also has a unique site, indicating overlapping mechanisms of action. With a rapid onset and a 4-7 hour duration, it effectively...
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Improving IV Insulin Administration in a Community Hospital
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Patients' Preferences for Insulin Injection Devices.

Andreas Pfützner1

  • 11 Pfützner Science & Health Institute, Mainz, Germany.

Journal of Diabetes Science and Technology
|March 7, 2017
PubMed
Summary

New insulin glargine U300 injection pens are easy to use and preferred by patients with type 2 diabetes. This study suggests good usability for this new prefilled insulin device in clinical practice.

Area of Science:

  • Endocrinology
  • Diabetes Management
  • Medical Device Technology

Background:

  • Type 2 diabetes requires effective insulin therapy, often involving injection devices.
  • Prefilled insulin pens aim to improve patient adherence and ease of use.
  • Regulatory agencies mandate human factor studies for medical devices.

Purpose of the Study:

  • To assess the ease of use and learning curve of a new prefilled insulin glargine U300 injection pen.
  • To evaluate patient preference and treatment satisfaction with the new device.
  • To understand the usability of the U300 insulin glargine pen in insulin-naïve type 2 diabetes patients.

Main Methods:

  • Device assessment study involving insulin-naïve patients with type 2 diabetes.
  • Evaluation of human factors, including ease of use and learning.
Keywords:
ease of usehuman factor studyinsulin injection pen devicepatient preference

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  • Patient preference and treatment satisfaction questionnaires administered.

    • Main Results:

    • Patients found the new prefilled insulin glargine U300 pen easy to learn and use.
    • Treatment satisfaction remained stable despite the introduction of injection therapy.
    • The device was accepted by the target patient population.

    Conclusions:

    • The new prefilled insulin glargine U300 injection pen demonstrates favorable usability and patient acceptance.
    • While limitations like small sample size and short duration exist, the findings are encouraging for clinical adoption.
    • Further studies may be needed to confirm long-term efficacy and broader applicability.