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Screening in Maternity to Ascertain Tuberculosis Status (SMATS) study
Edward Broughton1, Samson Haumba2, Marianne Calnan3
1Director of Research and Evaluation, University Research Co., LLC (URC), Bethesda, USA. ebroughton@urc-chs.com.
BMC Infectious Diseases
|March 8, 2017
Summary
Diagnosing tuberculosis in pregnant and HIV-infected women is challenging due to overlapping symptoms. This study evaluates improved screening tools to better detect active TB cases in these vulnerable populations.
Area of Science:
- Public Health
- Infectious Diseases
- Maternal Health
Background:
- Tuberculosis (TB) diagnosis is complicated in pregnant women due to symptom overlap with pregnancy.
- HIV infection can mask or alter TB symptoms, further complicating diagnosis.
- The current WHO four-symptom screening tool may miss active TB cases in pregnant and lactating women.
Purpose of the Study:
- To evaluate the sensitivity and specificity of the current TB screening tool for pregnant and lactating women (HIV-positive and negative).
- To assess enhanced screening algorithms using LAM, IGRA, TST, and chest radiography.
Main Methods:
- Cross-sectional analytical study design in Swaziland.
- Inclusion of pregnant and lactating women up to six months post-delivery.
- Enrollment into four groups: HIV-infected pregnant, non-HIV-infected pregnant, HIV-infected lactating, and non-HIV-infected lactating women.
Main Results:
- Study is ongoing; results not yet available.
Conclusions:
- Improved screening tools are needed to accurately diagnose TB in pregnant and lactating women, especially those with HIV.
- Further research is crucial to enhance TB detection sensitivity and specificity in this population.
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