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Prophylaxis with Isavuconazole or Posaconazole Protects Immunosuppressed Mice from Pulmonary Mucormycosis

Teclegiorgis Gebremariam1, Sondus Alkhazraji1, Clara Baldin1

  • 1Division of Infectious Diseases, Los Angeles Biomedical Research Institute at Harbor-University of California Los Angeles (UCLA) Medical Center and St. John's Cardiovascular Research Center, Torrance, California, USA.

Antimicrobial Agents and Chemotherapy
|March 8, 2017
PubMed

Insights

Isavuconazole and posaconazole show promise for preventing and treating pulmonary mucormycosis in mice. These antifungal therapies significantly improved survival and reduced fungal burden in infected, immunosuppressed rodents.

Area of Science:

  • Mycology
  • Infectious Diseases
  • Pharmacology

Background:

  • Pulmonary mucormycosis is a severe fungal infection with high mortality.
  • Limited effective treatment options exist for mucormycosis, necessitating research into novel antifungal therapies.

Purpose of the Study:

  • To evaluate the efficacy of isavuconazole, posaconazole, and voriconazole for treating pulmonary mucormycosis in an immunosuppressed murine model.
  • To compare prophylactic and continuous treatment strategies for these antifungal agents.

Main Methods:

  • Immunosuppressed mice infected with *Rhizopus delemar* were treated with prophylactic or continuous regimens of isavuconazole, posaconazole, or voriconazole.
  • Survival rates and fungal burden in lung tissue were assessed to determine treatment efficacy.

Main Results:

  • Prophylactic isavuconazole significantly improved survival and reduced fungal burden compared to placebo.
  • Continuous therapy with isavuconazole and posaconazole, but not voriconazole, prolonged survival and lowered fungal burden.
  • Isavuconazole demonstrated efficacy in both prophylactic and continuous treatment settings.

Conclusions:

  • Isavuconazole and posaconazole are effective in treating pulmonary mucormycosis in mice, particularly in prophylactic settings.
  • These findings support the clinical investigation of isavuconazole and posaconazole for mucormycosis treatment.
  • Voriconazole showed limited efficacy in this murine model of pulmonary mucormycosis.
Keywords:
Rhizopus delemarisavuconazolemucormycosismurineposaconazoleprophylaxisvoriconazole

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