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Related Experiment Video

Updated: Mar 6, 2026

Isolation and Cultivation of Neural Progenitors Followed by Chromatin-Immunoprecipitation of Histone 3 Lysine 79 Dimethylation Mark

Isolation and Cultivation of Neural Progenitors Followed by Chromatin-Immunoprecipitation of Histone 3 Lysine 79 Dimethylation Mark

Published on: January 26, 2018

Deciphering cell-cell communication in the developing mammalian brain.

Scott A Yuzwa¹, Freda D Miller²

¹Program in Neurosciences and Mental Health, Hospital for Sick Children , Toronto, Canada.

Neurogenesis (Austin, Tex.)

|March 8, 2017

Summary

This summary is machine-generated.

Researchers uncovered a complex growth factor network controlling embryonic neurogenesis. This discovery identified new regulators of cortical neuron development, enhancing our understanding of brain formation.

Keywords:

cell-cell interactions cortex development growth factors transcriptomics

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Last Updated: Mar 6, 2026

Isolation and Cultivation of Neural Progenitors Followed by Chromatin-Immunoprecipitation of Histone 3 Lysine 79 Dimethylation Mark

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Published on: January 26, 2018

Live Imaging of Mitosis in the Developing Mouse Embryonic Cortex

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Published on: June 4, 2014

A Comparative Approach for Quantitative Cell Counting Studies in Widely Different Mammalian Brains

A Comparative Approach for Quantitative Cell Counting Studies in Widely Different Mammalian Brains

Published on: January 16, 2026

Area of Science:

Neuroscience
Developmental Biology
Genetics

Background:

Mammalian cerebral cortex development involves diverse neuron subtypes originating from neural precursor cells during embryonic neurogenesis.
Neurogenesis is regulated transcriptionally and translationally, but extrinsic factors also play a significant role.
Understanding cell-cell communication is crucial for deciphering neurogenesis control.

Purpose of the Study:

To characterize cell-cell communication between cortical neurons and precursor cells.
To identify novel regulators of cortical neurogenesis through analysis of communication networks.
To explore extrinsic or niche control mechanisms in embryonic neurogenesis.

Main Methods:

Utilized a combination of computational and biological approaches.
Analyzed cell-cell communication networks within the developing cerebral cortex.
Validated predicted regulators of neurogenesis through experimental methods.

Main Results:

Revealed a complex growth factor communication network between cortical neurons and precursor cells.
The identified network accurately predicted previously unknown regulators of cortical neurogenesis.
Demonstrated the significant impact of extrinsic signaling on neurogenesis.

Conclusions:

Extrinsic signaling and cell-cell communication are critical for regulating the complexity of mammalian cortical neurogenesis.
The discovered growth factor network provides a framework for identifying new therapeutic targets for neurodevelopmental disorders.
Computational and biological integration offers a powerful approach to uncovering complex biological regulatory mechanisms.