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Related Concept Videos

Disorders of Leukocytes01:27

Disorders of Leukocytes

2.2K
Leukocyte disorders can lead to either leukopenia, characterized by an abnormally low leukocyte count, or leukocytosis, marked by a very high leukocyte number.
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune...
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Types of Fever01:25

Types of Fever

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Fever can be triggered by several factors, including infections, nervous system disorders, certain cancers, blood diseases like leukemia, embolism, thrombosis, heatstroke, dehydration, surgical trauma, crushing injuries, and allergic reactions.
Here are the different types of fever:
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Structure and Function of Leukocytes01:21

Structure and Function of Leukocytes

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An adult in good health typically has between 4,500 and 11,000 leukocytes, or white blood cells, per microliter of blood, which constitutes about 1% of the total blood volume. Unlike red blood cells, white blood cells contain a nucleus and other cellular organelles but do not have hemoglobin. Most white blood cells reside in connective tissues, particularly in lymphatic organs such as the lymph nodes, with only a small fraction present in circulating blood.
White blood cells protect the body...
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Patterns of Fever01:26

Patterns of Fever

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Before understanding the types and patterns of fever, it is essential to know its phases.
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Methods of reducing fever01:22

Methods of reducing fever

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The signs and symptoms of fever include hot and dry skin, flushed face, thirst, muscle aches, anorexia, headache, tachycardia, tachypnea, and fatigue. Elevated body temperature is reduced using two methods: pharmacological and nonpharmacological. Proper identification and treatment of the root cause of a fever is of utmost importance.
Pharmacological Methods of Reducing Fever:
1.5K
Increased Body Temperature01:25

Increased Body Temperature

7.6K
A body temperature above  38°C  (100.4 °F) is known as fever or pyrexia, and a person with fever is termed 'febrile.' Typically, the hypothalamus, a part of the brain that acts as the body's thermostat, regulates body temperature through a thermoregulatory setpoint. It receives signals from cold and warm thermal receptors throughout the body and adjusts the body's temperature accordingly. Fever occurs when this hypothalamic setpoint is altered, usually in...
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Related Experiment Video

Updated: Mar 6, 2026

Rapid Magnetic-microbead Method for Efficient Purification of Low-density Neutrophils
08:14

Rapid Magnetic-microbead Method for Efficient Purification of Low-density Neutrophils

Published on: November 11, 2025

498

[Leukopenia with unclear fever].

S Mayer1, T Kündiger2, H Schrader2

  • 1Medizinische Klinik und Funktionsdiagnostik, Endoskopie, Sana Krankenhaus Gerresheim, Sana Kliniken Düsseldorf GmbH, Gräulinger Str. 120, 40625, Düsseldorf, Deutschland. SabineTheresia.Mayer@Sana.de.

Der Internist
|March 8, 2017
PubMed
Summary

Metamizole can cause agranulocytosis, a serious condition leading to neutropenic fever. Early diagnosis and treatment, including stopping metamizole and using granulocyte colony-stimulating factor (G-CSF), can lead to full recovery.

Area of Science:

  • Hematology
  • Pharmacology
  • Internal Medicine

Background:

  • Agranulocytosis is a severe adverse drug reaction.
  • Metamizole is a commonly used analgesic and antipyretic.
Keywords:
AgranulocytosisBiopsy, bone marrowDipyrone, adverse effectsFebrile neutropeniaGranulocyte colony-stimulating factor

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  • Drug-induced agranulocytosis is an underrecognized clinical entity.