Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Psychosurgery01:30

Psychosurgery

2.1K
Psychosurgery, the surgical alteration or permanent removal of brain tissue to alleviate severe psychological conditions, stands as one of the most radical and controversial treatments in the history of mental health care. Its development and application have evolved significantly, marked by dramatic shifts in scientific understanding and ethical perspectives.
Historical Development of Psychosurgery
In the 1930s, Portuguese neurologist Antonio Egas Moniz introduced a surgical procedure designed...
2.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[S3 Guideline Sepsis-prevention, diagnosis, therapy, and aftercare : Long version].

Medizinische Klinik, Intensivmedizin und Notfallmedizin·2020
Same author

[S3 guideline sepsis-prevention, diagnosis, treatment, and aftercare : Summary of the strong recommendations].

Medizinische Klinik, Intensivmedizin und Notfallmedizin·2020
Same author

Pain And The Use Of Gabapentinoids In German Nursing Home Residents - Results From An Analysis Based On Statutory Health Insurance Data.

Journal of pain research·2019
Same author

Current clinical use of intravenous fosfomycin in ICU patients in two European countries.

Infection·2019
Same author

[Hemodynamic effects of cafedrine/theodrenaline on anesthesia-induced hypotension].

Der Anaesthesist·2018
Same author

Between evidence and commerce - the case of sufentanil sublingual tablet systems.

Anaesthesia·2017
Same journal

Schmerz (Berlin, Germany)·2026
Same journal

Schmerz (Berlin, Germany)·2026
Same journal

Schmerz (Berlin, Germany)·2026
Same journal

[Postoperative pain and sex/gender-current findings of the past decade].

Schmerz (Berlin, Germany)·2026
Same journal

[Non-invasive neuromodulation for chronic pain : A review of eight current methods and the evidence].

Schmerz (Berlin, Germany)·2026
Same journal

[Pain medicine aspects of the updated S2k guideline "Diagnosis and treatment of endometriosis"].

Schmerz (Berlin, Germany)·2026
See all related articles

Related Experiment Video

Updated: Mar 6, 2026

Continuous Theta Burst Stimulation of the Posterior Medial Frontal Cortex to Experimentally Reduce Ideological Threat Responses
06:42

Continuous Theta Burst Stimulation of the Posterior Medial Frontal Cortex to Experimentally Reduce Ideological Threat Responses

Published on: September 28, 2018

12.3K

[Piritramide : A critical review].

M Hinrichs1, A Weyland2, C Bantel2

  • 1Universitätsklinik für Anästhesiologie/Intensivmedizin/Notfallmedizin/Schmerztherapie, Klinikum Oldenburg AöR, Rahel-Straus-Str. 10, 26133, Oldenburg, Deutschland. hinrichs.melanie@klinikum-oldenburg.de.

Schmerz (Berlin, Germany)
|March 8, 2017
PubMed
Summary
This summary is machine-generated.

Piritramide is a parenteral opioid analgesic used for pain management. Despite its use in Germany, evidence supporting its first-line status for postoperative pain is limited, with a need for more research on its pharmacology and dosing.

Keywords:
Analgesia, patient-controlledMorphinePain, postoperativePharmacodynamicsPharmacokinetics

More Related Videos

Prehospital Thrombolysis: A Manual from Berlin
05:52

Prehospital Thrombolysis: A Manual from Berlin

Published on: November 26, 2013

22.5K
Cardiac Magnetic Resonance for the Evaluation of Suspected Cardiac Thrombus: Conventional and Emerging Techniques
06:29

Cardiac Magnetic Resonance for the Evaluation of Suspected Cardiac Thrombus: Conventional and Emerging Techniques

Published on: June 11, 2019

11.3K

Related Experiment Videos

Last Updated: Mar 6, 2026

Continuous Theta Burst Stimulation of the Posterior Medial Frontal Cortex to Experimentally Reduce Ideological Threat Responses
06:42

Continuous Theta Burst Stimulation of the Posterior Medial Frontal Cortex to Experimentally Reduce Ideological Threat Responses

Published on: September 28, 2018

12.3K
Prehospital Thrombolysis: A Manual from Berlin
05:52

Prehospital Thrombolysis: A Manual from Berlin

Published on: November 26, 2013

22.5K
Cardiac Magnetic Resonance for the Evaluation of Suspected Cardiac Thrombus: Conventional and Emerging Techniques
06:29

Cardiac Magnetic Resonance for the Evaluation of Suspected Cardiac Thrombus: Conventional and Emerging Techniques

Published on: June 11, 2019

11.3K

Area of Science:

  • Pharmacology
  • Pain Management
  • Drug Effectiveness

Background:

  • Piritramide is a primary opioid analgesic in Germany for postoperative and posttraumatic pain.
  • Its widespread use as a first-line treatment is common in European countries.

Purpose of the Study:

  • To review the pharmacological properties of piritramide.
  • To assess clinical advantages in effectiveness, safety, and side effect profiles compared to other strong opioids.

Main Methods:

  • A systematic literature search was performed in PubMed and Google Scholar.
  • 27 articles published between 1961 and 2015 were included in the review.

Main Results:

  • Piritramide is a parenterally administered strong opioid, effective within 17 minutes for up to 6 hours.
  • Metabolized in the liver to inactive compounds, it offers an advantage over morphine in renal failure patients.
  • High lipophilicity leads to a long context-sensitive half-life, unsuitable for continuous infusions; side effect profile is comparable to morphine.

Conclusions:

  • Limited evidence supports piritramide's first-line use for postoperative pain in Germany.
  • Further research is needed on its mechanisms of action, receptor pharmacology, and clinical dosing.
  • The prioritization of piritramide warrants further investigation given the current evidence gaps.