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Related Experiment Video

Updated: Mar 6, 2026

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Using exposure bands for rapid decision making in the RISK21 tiered exposure assessment.

M Dellarco1, R Zaleski2, B J Gaborek3

  • 1a National Children?s Study, Eunice Kennedy Shriver National Institute of Child Health and Human Development , Bethesda , MD , USA.

Critical Reviews in Toxicology
|March 8, 2017
PubMed
Summary
This summary is machine-generated.

The RISK21 project developed an exposure-driven roadmap and visualization tool to improve human health risk assessments. Screening-level exposure estimates were found to be conservative and suitable for risk evaluation.

Keywords:
Exposure bandingRISK21exposure assessmenthigh throughputrisk assessmentscreening

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Area of Science:

  • Environmental Health Sciences
  • Toxicology
  • Risk Assessment Methodology

Background:

  • Human health risk assessment requires efficient and transparent methods for evaluating hazard and exposure.
  • Existing risk assessment frameworks can be improved through structured, problem-formulation-based approaches.

Purpose of the Study:

  • To introduce the ILSI Health and Environmental Sciences Institute (HESI) Risk Assessment in the Twenty-first Century (RISK21) project.
  • To describe the exposure tiers and screening-level approaches within the RISK21 matrix.
  • To evaluate the utility of the RISK21 approach using a case study.

Main Methods:

  • Developed exposure look-up tables from existing tools (ECETOC TRA, ESIG EGRET, USEtox®).
  • Applied these tables to estimate screening-level exposure for worker, consumer, and indirect exposure scenarios.
  • Validated the RISK21 approach against a World Health Organization (WHO) risk assessment for mosquito bed netting.

Main Results:

  • Screening-level methodologies using adapted information provided suitable conservative exposure estimates.
  • The hypothetical mosquito bed netting case study demonstrated the practicality of the approach.
  • The RISK21 matrix effectively facilitated transparent evaluation of exposure components.

Conclusions:

  • The RISK21 approach is a valuable tool for problem formulation and defining future risk assessment efforts.
  • The exposure-driven roadmap and visualization tool enhance the focus and transparency of risk assessments.
  • RISK21 aids in visualizing results and guiding subsequent assessment activities.