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Related Concept Videos

Skin Diseases and Disorders01:23

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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
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Papillary Dermis01:11

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Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
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Reticular Dermis01:15

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The papillary and reticular dermis are the two layers of the dermis. They are made of connective tissue with fibers of collagen extending from one to the other, making the border between the two somewhat indistinct. The dermal papillae extending into the epidermis belong to the papillary layer, whereas the dense collagen fiber bundles below belong to the reticular layer.
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Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
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Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus
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Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus

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Darier's Disease.

B M S Bedi, B R Garg

    Indian Journal of Dermatology, Venereology and Leprology
    |March 8, 2017
    PubMed
    Summary
    This summary is machine-generated.

    Darier's disease, a genetic skin disorder, often presents in childhood with itching and typical lesions. This study highlights unusual findings like hand/foot lesions and mucosal involvement, emphasizing the need for broader clinical awareness.

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    Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis
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    Area of Science:

    • Dermatology
    • Genetics
    • Clinical Medicine

    Background:

    • Darier's disease is a rare autosomal dominant genodermatosis.
    • Clinical manifestations can vary significantly among affected individuals.
    • Understanding the full spectrum of Darier's disease symptoms is crucial for accurate diagnosis and management.

    Purpose of the Study:

    • To investigate the clinical presentation and unusual manifestations of Darier's disease.
    • To correlate disease severity with duration and other clinical factors.
    • To emphasize less commonly reported features in clinical practice.

    Main Methods:

    • Retrospective case series analysis of fifteen patients diagnosed with Darier's disease.
    • Detailed clinical examination and review of patient histories.
    • Documentation of lesion types, symptom prevalence, and disease course.

    Main Results:

    • The study included a 3:2 male to female ratio, with onset typically between ages 5-16.
    • Itching (66.6%) was the primary symptom; 60% had a positive family history.
    • All patients exhibited acrokeratosis verruciformis-like lesions; 86.6% had palmoplantar keratoderma, and 73.3% showed mucosal lesions. Leucoderma guttate was noted in 20%.

    Conclusions:

    • Darier's disease presents with a wider range of manifestations than commonly recognized, including significant palmoplantar, acral, and mucosal involvement.
    • Disease severity correlates with its duration.
    • Increased clinical awareness of these less-stressed findings is essential for comprehensive patient care.