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Serologic characteristics of a human rotavirus isolate, AU-1, which has a "long" RNA pattern and subgroup I
S Kitaoka1, T Nakagomi, N Fukuhara
1Department of Pediatrics, Tohoku University, Sendai, Japan.
Journal of Medical Virology
|December 1, 1987
Abstract:
An unusual human rotavirus (HRV) isolate, designated AU-1, has a "long" RNA electrophoretic pattern and subgroup I specificity, in contrast to properties common to HRVs previously isolated. Hemagglutination activity of the AU-1 strain was demonstrated using erythrocytes of 1-day-old chicken. Neutralization assays revealed that the AU-1 strain was crossneutralized by hyperimmune antisera against the MO strain (serotype 3). However, antiserum directed against a reassortant in which the gene for Vp7 was replaced by the corresponding AU-1 gene neutralized the AU-1 strain to a significantly higher titer than the MO strain.