Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A Systematic Review of Factors Influencing Adult Adherence to Topical Medications in Atopic Dermatitis.

American journal of clinical dermatology·2026
Same author

Is diagnosis of Cushing's disease moving beyond Bilateral inferior petrosal sinus sampling?

The Journal of clinical endocrinology and metabolism·2026
Same author

Spatially heterogeneous power-law attenuation with multiple relaxation mechanisms for ultrasound modeling.

ArXiv·2026
Same author

Triglyceride glucose index versus triglyceride glucose-BMI index in non-alcoholic fatty liver disease: A correlation with steatosis and fibrosis.

Bioinformation·2026
Same author

Toward harmonizing ultrasound-based cortical bone characterization: A comparison of attenuation measurement techniques.

The Journal of the Acoustical Society of America·2026
Same author

Forward-viewing intravascular ultrasound: Design and fabrication for high sensitivity 3D imaging of hemodynamics.

IEEE transactions on bio-medical engineering·2026

Related Experiment Video

Updated: Mar 6, 2026

Imaging and Quantification of the Area of Fast-Moving Microbubbles Using a High-Speed Camera and Image Analysis
05:31

Imaging and Quantification of the Area of Fast-Moving Microbubbles Using a High-Speed Camera and Image Analysis

Published on: September 5, 2020

6.4K

An iterative fullwave simulation approach to multiple scattering in media with randomly distributed microbubbles.

Aditya Joshi1, Brooks D Lindsey2, Paul A Dayton2

  • 1Department of Mechanical and Aerospace Engineering, NC State University, Raleigh, NC, United States of America.

Physics in Medicine and Biology
|March 8, 2017
PubMed
Summary
This summary is machine-generated.

This study introduces a novel model combining acoustic wave propagation and microbubble nonlinear dynamics. The model accurately predicts ultrasound contrast agent behavior, improving diagnostic imaging capabilities.

More Related Videos

Induction of Microstreaming by Nonspherical Bubble Oscillations in an Acoustic Levitation System
08:19

Induction of Microstreaming by Nonspherical Bubble Oscillations in an Acoustic Levitation System

Published on: May 9, 2021

2.8K
Multi-timescale Microscopy Methods for the Characterization of Fluorescently-labeled Microbubbles for Ultrasound-Triggered Drug Release
06:02

Multi-timescale Microscopy Methods for the Characterization of Fluorescently-labeled Microbubbles for Ultrasound-Triggered Drug Release

Published on: June 12, 2021

4.4K

Related Experiment Videos

Last Updated: Mar 6, 2026

Imaging and Quantification of the Area of Fast-Moving Microbubbles Using a High-Speed Camera and Image Analysis
05:31

Imaging and Quantification of the Area of Fast-Moving Microbubbles Using a High-Speed Camera and Image Analysis

Published on: September 5, 2020

6.4K
Induction of Microstreaming by Nonspherical Bubble Oscillations in an Acoustic Levitation System
08:19

Induction of Microstreaming by Nonspherical Bubble Oscillations in an Acoustic Levitation System

Published on: May 9, 2021

2.8K
Multi-timescale Microscopy Methods for the Characterization of Fluorescently-labeled Microbubbles for Ultrasound-Triggered Drug Release
06:02

Multi-timescale Microscopy Methods for the Characterization of Fluorescently-labeled Microbubbles for Ultrasound-Triggered Drug Release

Published on: June 12, 2021

4.4K

Area of Science:

  • Acoustics
  • Biomedical Engineering
  • Nonlinear Dynamics

Background:

  • Ultrasound contrast agents (UCAs) enhance blood echogenicity but their multiple scattering interactions with acoustic fields are complex and poorly understood.
  • Existing models often treat UCAs as isolated bubbles or analyze multiple scattering and nonlinear dynamics separately, limiting accuracy.
  • Accurate modeling is crucial for advancing ultrasound imaging and understanding UCA behavior in biological tissues.

Purpose of the Study:

  • To develop and validate a novel computational approach that integrates nonlinear acoustic wave propagation with microbubble nonlinear dynamics.
  • To investigate the convergence and accuracy of the combined model for predicting UCA backscattering, phase velocity, and attenuation.
  • To provide a more comprehensive simulation tool for ultrasound contrast agent behavior in heterogeneous media.

Main Methods:

  • Combined a full-wave model for nonlinear acoustic propagation in heterogeneous media with the Paul-Sarkar model for microbubble nonlinear response.
  • Employed a numerical iterative approach to solve the coupled model.
  • Performed in silico convergence studies at various microbubble concentrations (0.5 × 10^6 microbubbles/mL, 1%, 2% volume).
  • Validated model predictions against experimental water tank measurements using a 128-element linear array transducer.

Main Results:

  • The combined model demonstrated excellent agreement with experimental measurements of fundamental and harmonic acoustic fields.
  • The model accurately predicted phase velocity and attenuation, consistent with through-transmission measurements and the independent scattering approximation.
  • In silico studies confirmed model convergence at tested microbubble concentrations.

Conclusions:

  • The developed integrated model successfully captures the complex multiple scattering and nonlinear dynamics of ultrasound contrast agents.
  • This approach offers a significant advancement over existing models, enabling more accurate predictions of UCA behavior.
  • The validated model has the potential to enhance the interpretation of ultrasound imaging and guide the development of new contrast agents.