Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Nociception01:44

Nociception

33.5K
Nociception—the ability to feel pain—is essential for an organism’s survival and overall well-being. Noxious stimuli such as piercing pain from a sharp object, heat from an open flame, or contact with corrosive chemicals are first detected by sensory receptors, called nociceptors, located on nerve endings. Nociceptors express ion channels that convert noxious stimuli into electrical signals. When these signals reach the brain via sensory neurons, they are perceived as pain.
33.5K
Local Anesthetics: Differential Sensitivity of Nerve Fibers01:24

Local Anesthetics: Differential Sensitivity of Nerve Fibers

1.5K
Local anesthetics (LAs) block the sodium channels of nerve trunks, sensory nerve endings, and neuromuscular junctions. Although LAs can block all kinds of nerves, the sensitivity of nerve fibers differs according to nerve types and structures. LAs are known to block myelinated fibers faster than unmyelinated ones. Also, they block pain or sensory neurons at low concentrations without affecting the motor neurons involved in muscle contractions. This helps relieve labor pain without affecting the...
1.5K
Chemotherapy-Induced Nausea and Vomiting: Dopamine Receptor Antagonists01:29

Chemotherapy-Induced Nausea and Vomiting: Dopamine Receptor Antagonists

992
Dopamine receptor antagonists, also known as antipsychotic agents, are critical in managing chemotherapy-induced vomiting. These antiemetic agents block dopamine receptors in the chemoreceptor trigger zone (CTZ), inhibiting signal transmission to the vomiting center. Antipsychotic agents encompass phenothiazines (PTZ), butyrophenones, benzamides, and thienobenzodiazepines (Zyprexa), which are utilized for their antiemetic and sedative properties.
Phenothiazines, such as prochlorperazine...
992
Analgesia and Pain Management01:25

Analgesia and Pain Management

2.5K
Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
2.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Endocannabinoid cerebrospinal fluid levels in migraine and its relation to symptoms of depression.

Cephalalgia : an international journal of headache·2026
Same author

Expert perspectives on the nociplastic pain descriptor: a systematic review of textual evidence protocol.

JBI evidence synthesis·2026
Same author

Early supraclavicular nerve grafting or distal nerve transfer for restoration of elbow flexion in incomplete adult traumatic brachial plexus injuries.

Brain & spine·2026
Same author

Thoracic sympathetic block with botulinum toxin A for complex regional pain syndrome: a retrospective case series.

Interventional pain medicine·2026
Same author

Comment on Bilika et al. Applying Nociplastic Pain Criteria in Chronic Musculoskeletal Conditions: A Vignette Study. <i>J. Clin. Med.</i> 2025, <i>14</i>, 1179.

Journal of clinical medicine·2026
Same author

Autonomic Receptor Autoantibodies in Complex Regional Pain Syndrome and Other Chronic Pain Conditions: A Cross-Sectional Analysis.

Biomedicines·2026

Related Experiment Video

Updated: Mar 6, 2026

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
10:39

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

Published on: June 2, 2014

18.8K

Allodynia in cluster headache.

Leopoldine A Wilbrink1, Mark A Louter, Onno P M Teernstra

  • 1Departments of aNeurology and bPsychiatry, Leiden University Medical Centre, Leiden, the Netherlands cDepartment of Neurosurgery, Maastricht University Medical Centre, Maastricht, the Netherlands dDepartment of Medical Statistics and BioInformatics, Leiden University Medical Centre, Leiden, the Netherlands eDepartment of Anaesthesiology, Erasmus MC, Rotterdam, the Netherlands fDepartment of Neurology, Alrijne Hospital, Leiderdorp, the Netherlands.

Pain
|March 8, 2017
PubMed
Summary

Cutaneous allodynia, a marker of central sensitization, is present in 36% of cluster headache patients. Female gender, early onset, depression, migraine comorbidity, and recent attacks are key risk factors, suggesting central sensitization in cluster headache.

More Related Videos

Dural Stimulation and Periorbital von Frey Testing in Mice As a Preclinical Model of Headache
05:40

Dural Stimulation and Periorbital von Frey Testing in Mice As a Preclinical Model of Headache

Published on: July 29, 2021

10.0K
Demonstration of Cutaneous Allodynia in Association with Chronic Pelvic Pain
06:44

Demonstration of Cutaneous Allodynia in Association with Chronic Pelvic Pain

Published on: June 23, 2009

20.5K

Related Experiment Videos

Last Updated: Mar 6, 2026

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
10:39

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

Published on: June 2, 2014

18.8K
Dural Stimulation and Periorbital von Frey Testing in Mice As a Preclinical Model of Headache
05:40

Dural Stimulation and Periorbital von Frey Testing in Mice As a Preclinical Model of Headache

Published on: July 29, 2021

10.0K
Demonstration of Cutaneous Allodynia in Association with Chronic Pelvic Pain
06:44

Demonstration of Cutaneous Allodynia in Association with Chronic Pelvic Pain

Published on: June 23, 2009

20.5K

Area of Science:

  • Neurology
  • Pain Medicine
  • Headache Disorders

Background:

  • Cutaneous allodynia is a recognized indicator of central sensitization in migraine.
  • The presence and implications of allodynia in cluster headache remain debated.
  • Understanding allodynia in cluster headache is crucial for advancing treatment strategies.

Purpose of the Study:

  • To investigate the prevalence and severity of cutaneous allodynia in a large, well-defined population of individuals with cluster headache.
  • To identify risk factors associated with allodynia in cluster headache patients.
  • To explore the potential role of central sensitization in cluster headache.

Main Methods:

  • Cross-sectional study utilizing validated questionnaires within the Leiden University Cluster headache neuro-Analysis (LUCA) study.
  • Diagnosis of cluster headache confirmed using International Classification of Headache Disorders criteria.
  • Multivariate regression models were employed to analyze ictal allodynia, comorbid depression, migraine, and demographic factors, adjusting for cluster headache subtype and attack recency.

Main Results:

  • A significant prevalence of 36% (218/606) of cluster headache participants reported experiencing allodynia during attacks.
  • Independent risk factors for allodynia included female gender, lower age at onset, lifetime history of depression, comorbid migraine, and recent cluster headache attacks.
  • Factors such as attack duration and chronic cluster headache subtype did not emerge as significant independent risk factors.

Conclusions:

  • The high prevalence of cutaneous allodynia in cluster headache, coupled with similar risk factors to those observed in migraine, strongly suggests the presence of central sensitization.
  • These findings indicate that central sensitization may be a shared pathophysiological mechanism between migraine and cluster headache.
  • Clinical awareness of allodynia in cluster headache patients is essential for refining future treatment approaches and improving patient management.