Regulating Damage from Sterile Inflammation: A Tale of Two Tolerances.
1Graduate Program in Immunology, University of Michigan Medical School, Ann Arbor, MI, USA; Department of Internal Medicine, Michigan Medicine, Ann Arbor, MI, USA.
Trends in Immunology
|March 8, 2017
Summary
Target tissues play a crucial role in sterile immunopathology. This study introduces
Area of Science:
- Immunology
- Pathology
- Cell Biology
Background:
- Non-infectious inflammation severity is primarily linked to immune cell activity.
- The contribution of target tissues to damage severity in sterile immunopathology is underappreciated.
Purpose of the Study:
- To explore the concept of 'tissue tolerance' in mitigating organ damage.
- To highlight the significance of tissue-intrinsic programs in sterile inflammation.
Main Methods:
- Conceptual discussion and literature review.
- Analysis of existing data on sterile immunopathology.
Main Results:
- Identified 'tissue tolerance' as a key factor in ameliorating organ damage.
- Highlighted the overlooked role of tissue-intrinsic mechanisms.
Conclusions:
- Target tissues possess intrinsic programs that influence immunopathology.
- Understanding tissue tolerance is essential for managing sterile inflammation and organ damage.
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