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Updated: Mar 6, 2026

Improving IV Insulin Administration in a Community Hospital
Published on: June 11, 2012
Nonlinear model predictive glycemic control of critically ill patients using online identification of insulin
Abstract:
In critically ill patients suffering from hyperglycemia, it has been recently shown that mortality and morbidity can be reduced by keeping blood glucose within the range of 80-110 mg/dL. However, maintaining glycemia within such range is difficult due to the time variability in insulin sensitivity in critically ill patients. In this paper, we propose a novel glycometabolism model of critically ill patients with an insulin sensitivity parameter and develop a nonlinear model predictive glycemic control system with online identification of insulin sensitivity at one-hour intervals. Simulation results show that our system keeps 70% of BG measurements within the range of 80-110 mg/dL without any severe hypoglycemic incidents, which indicates the effectiveness and safety of our system.
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