Quantitative estimation of electro-osmosis force on charged particles inside a borosilicate resistive-pulse sensor

Area of Science:

• Nanotechnology
• Biomolecular Sensing
• Physical Chemistry

Background:

• Nano and micron-scale pore sensors offer sensitive, label-free, and cost-effective biomolecular detection.
• Electrophoretic and electroosmotic forces are critical determinants of sensor performance.

Purpose of the Study:

• To develop a mathematical model for predicting particle behavior in nanopore sensors.
• To quantify the interplay between electrophoretic and electroosmotic forces.

Main Methods:

• Experimental and simulation data of negatively charged particles in a borosilicate pore were utilized.
• A mathematical model was developed to analyze particle dynamics under an applied electric field.

Main Results:

• The study focused on particles traversing a 2μm diameter solid-state borosilicate pore.
• The developed model estimated the electroosmosis force to electrophoretic force ratio at 77.5%.

Conclusions:

• The mathematical model provides insights into the forces governing particle transport in nanopore sensors.
• Understanding these forces is crucial for optimizing the design and performance of biosensing devices.