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    This study introduces a novel Biomedical Microelectromechanical System (BioMEMS) sensor for smartphone-based biomarker detection. The portable sensor offers encrypted data at the physical level, ensuring patient privacy while maintaining accurate diagnostic results.

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    Area of Science:

    • Biomedical Engineering
    • Sensor Technology
    • Point-of-Care Diagnostics

    Background:

    • Effective point-of-care diagnostics require rapid, accurate disease detection.
    • Privacy-preserving capabilities are crucial for portable health solutions.
    • Existing solutions may lack integrated physical-level data security.

    Purpose of the Study:

    • To develop a portable, inexpensive Biomedical Microelectromechanical System (BioMEMS) sensor for smartphone-based biomarker detection.
    • To integrate physical-level signal encryption for patient diagnostic confidentiality.
    • To validate the sensor's ability to protect sample measurements while distinguishing between test samples.

    Main Methods:

    • Design and fabrication of a novel BioMEMS sensor.
    • Integration of signal encryption at the physical sensor level.
    • Testing and validation using distinct biological samples.

    Main Results:

    • The developed BioMEMS sensor enables portable and inexpensive biomarker detection via smartphones.
    • Physical-level signal encryption successfully protected sample measurements.
    • The sensor accurately distinguished between different test samples, demonstrating diagnostic utility.

    Conclusions:

    • The proposed BioMEMS sensor offers a promising solution for secure and accurate point-of-care diagnostics.
    • Physical-level encryption enhances patient confidentiality in mobile health applications.
    • This technology facilitates trustworthy and usable portable diagnostic tools.