Non-invasive cardiac output monitoring in pharmacology: A plethysmographie solution in rats

Cardiovascular monitoring is of great importance in pharmacology but there is a lack of convenient non-invasive alternatives. Hence, we aim to evaluate the relevance of inductive plethysmography (IP) in preclinical cardiac studies. An IP system was specifically designed for rat. Its evaluation carried out using a mechanical test bench has shown appropriate instrumental performances for cardiac monitoring in rats. Measurements were also performed during a volume overload hemodynamic challenge in vivo in rats. The cardiac output variation has similar kinetic and amplitude when compared to results of previous studies. This suggests that our system is suitable for cardiac output monitoring in rat.