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The effect of hydroxyl radical scavenging on acute axial-random skin flap survival
R E Hayden1, R C Paniello, C S Yeung
1Department of Otolaryngology, Washington University School of Medicine, St. Louis, MO 63110.
The Laryngoscope
|January 1, 1988
Abstract:
Dimethyl thiourea (DMTU), a known hydroxyl radical scavenger, was tested for its ability to improve survival in acute island skin flaps. Rats receiving 500 mg/kg DMTU 1 hour after flap elevation showed a 23.5% improved survival over saline controls. The role of the hydroxyl radical in ischemia/reperfusion injury, and its proposed mechanism, is discussed.