An implementation for the simulation of cells on micro-post arrays

Area of Science:

• Biomechanics
• Cellular mechanics
• Biomaterials science

Background:

• Cell-substrate mechanical interactions are crucial for understanding biological processes at tissue-implant interfaces.
• Existing research extensively studies these interactions through experimental and numerical methods.
• The Deshpande et al. bio-chemo-mechanical model offers significant applications and advantages for analyzing cell contractility.

Purpose of the Study:

• To provide a practical implementation of the Deshpande et al. bio-chemo-mechanical model within COMSOL Multiphysics.
• To facilitate straightforward modification and extension of the model for future research.
• To establish a foundation for coupling the model with external stimuli.

Main Methods:

• Implementation of a bio-chemo-mechanical model for cell contractility.
• Utilizing COMSOL Multiphysics software for numerical modeling.
• Developing a modifiable and extensible framework for the differential system.

Main Results:

• Successful implementation of the bio-chemo-mechanical model in COMSOL Multiphysics.
• Creation of a user-friendly platform for researchers to adapt the model.
• Demonstration of the model's potential for integration with external factors.

Conclusions:

• The COMSOL implementation simplifies the application and adaptation of the cell contractility model.
• This work paves the way for advanced studies coupling mechanical and external stimuli.
• Enhanced understanding of cell-substrate interactions can be achieved through this adaptable modeling approach.