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Published on: November 16, 2018
Improving the biocompatibility of tobermorite by incorporating calcium phosphate clusters
Hirotaka Maeda1, Tomoyuki Tamura2, Toshihiro Kasuga1
1Department of Life Science and Applied Chemistry, Nagoya Institute of Technology, Gokiso-cho, Showa-ku, Nagoya 466-8555, Japan.
Background:
In our earlier work, tobermorite containing calcium phosphate (CP) clusters (CP-Tob) was hydrothermally prepared in the CaO-SiO2-P2O5-H2O system for biomedical applications.
Objective:
CP-Tob was used to investigate the influence of CP cluster incorporation on its biocompatibility.
Methods:
Tobermorite samples with and without CP clusters were hydrothermally prepared at 180°C for 40 h. The biocompatibility, structure, and density of states of the tobermorite samples were investigated by experimental and first principles methods.
Results:
The amounts of lysozyme and bovine serum albumin adsorbed on CP-Tob were higher than those on tobermorite without CP clusters. Cluster incorporation caused a decrease in the solubility, resulting in the enhancement of the cell compatibility. The calculated results indicated that incorporating clusters, which interact with the silicate units of tobermorite, led to a change of the density of states of tobermorite.
Conclusions:
Incorporation of CP clusters in tobermorite led to improvement of the biocompatibility evaluated by biological and computational analyses.
