Related Experiment Video
Updated: Mar 6, 2026

Global and Current Research Trends of Single-Cell Sequencing in Cancer: A Bibliometric and Visualization Study
Published on: April 18, 2025
Topological-Pattern-Based Recommendation of UMLS Concepts for National Cancer Institute Thesaurus
Zhe He1, Yan Chen2, Sherri de Coronado3
1School of Information, Florida State University, Tallahassee, FL; Institute for Successful Longevity, Florida State University, Tallahassee, FL.
Abstract:
The National Cancer Institute Thesaurus (NCIt) is a reference terminology used to support clinical, translational and basic research as well as administrative activities. As medical knowledge evolves, concepts that might be missing from a particular needed subdomain are regularly added to the NCIt. However, terminology development is known to be labor-intensive and error-prone. Therefore, cost-effective semi-automated methods for identifying potentially missing concepts would be useful to terminology curators. Previously, we have developed a structural method leveraging the native term mappings of the Unified Medical Language System to identify potential concepts in several of its source vocabularies to enrich the SNOMED CT. In this paper, we tested an analogous method for NCIt. Concepts from eight UMLS source terminologies were identified as possibilities to enrich NCIt's conceptual content.
More Related Videos
Related Concept Videos
Combination Therapies and Personalized Medicine
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
Metastasis
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
lncRNA - Long Non-coding RNAs
Anatomical Terminology
Cancer-Critical Genes II: Tumor Suppressor Genes
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
Tumor Progression
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...

