Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Development of the Lymphatic System01:15

Development of the Lymphatic System

2.4K
The development of lymphatic tissues and vessels in embryonic life begins around the fifth week. These structures originate from the mesoderm layer, with lymph sacs emerging from developing veins.
The first lymph sacs to form are the paired jugular lymph sacs located at the junction of the internal jugular and subclavian veins. From these sacs, lymphatic capillary plexuses extend to the thorax, upper limbs, neck, and head, eventually forming lymphatic vessels. Each jugular lymph sac maintains a...
2.4K
Cranial Bones: Superior and Posterior View01:14

Cranial Bones: Superior and Posterior View

8.3K
The superior view of the cranium shows the frontal and paired parietal bones.
The frontal bone is the single bone that forms the forehead. At its anterior midline, between the eyebrows, there is a slight depression called the glabella. The frontal bone also forms the supraorbital margin of the orbit. Near the middle of this margin is the supraorbital foramen, the opening that provides passage for a sensory nerve to the forehead. The frontal bone is thickened just above each supraorbital margin,...
8.3K
Veins of Head and Neck01:19

Veins of Head and Neck

6.4K
The blood drainage from the head and neck is primarily managed by three pairs of veins: the external jugular, internal jugular, and vertebral veins. The external jugular veins drain superficial scalp and face structures, passing over the sternocleidomastoid muscles to empty into the subclavian veins.
On the other hand, the vertebral veins, unlike their arterial counterparts, are not primarily responsible for brain drainage. Instead, they drain the cervical vertebrae, spinal cord, and some small...
6.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Combining Real-World and Clinical Trial Data Through Privacy-Preserving Record Linkage: Opportunities and Challenges-A Narrative Review.

Health science reports·2025
Same author

An observational post-authorization study to assess the effectiveness of a single dose Ad26.COV2.S for the prevention of COVID-19 using real-world data.

Frontiers in public health·2024
Same author

Racial and Ethnic Disparities in the Time to Ovarian Cancer Surgery in Patients at an Integrated Health Care Delivery System.

Journal of the National Comprehensive Cancer Network : JNCCN·2024
Same author

A Case for Synthetic Data in Regulatory Decision-Making in Europe.

Clinical pharmacology and therapeutics·2023
Same author

High unmet treatment needs in patients with chronic kidney disease and type 2 diabetes: real-world evidence from a US claims database.

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association·2022
Same author

Durability of the Single-Dose Ad26.COV2.S Vaccine in the Prevention of COVID-19 Infections and Hospitalizations in the US Before and During the Delta Variant Surge.

JAMA network open·2022

Related Experiment Video

Updated: Mar 6, 2026

Author Spotlight: Overcoming Anti-VEGF Resistance Through Advanced Vascular Morphology Assessment in Choroidal Neovascularization
05:14

Author Spotlight: Overcoming Anti-VEGF Resistance Through Advanced Vascular Morphology Assessment in Choroidal Neovascularization

Published on: August 11, 2023

1.6K

Midline Capillary Formation Nuchae and Age.

Marvin H Klapman1, Michael Batech2

  • 1Department of Dermatology, Southern California Permanente Medical Group, Woodland Hills, CA; marvinklapman@gmail.com.

Skinmed
|March 9, 2017
PubMed
Summary
This summary is machine-generated.

Midline capillary formation nuchae (MCFN) prevalence increases with age, particularly in men. This common finding in older adults is not a risk factor for angiosarcoma but may reflect age-related neuroendocrine changes.

More Related Videos

State of the Art Cranial Ultrasound Imaging in Neonates
10:02

State of the Art Cranial Ultrasound Imaging in Neonates

Published on: February 2, 2015

26.3K
Automated Midline Shift and Intracranial Pressure Estimation based on Brain CT Images
14:08

Automated Midline Shift and Intracranial Pressure Estimation based on Brain CT Images

Published on: April 13, 2013

43.7K

Related Experiment Videos

Last Updated: Mar 6, 2026

Author Spotlight: Overcoming Anti-VEGF Resistance Through Advanced Vascular Morphology Assessment in Choroidal Neovascularization
05:14

Author Spotlight: Overcoming Anti-VEGF Resistance Through Advanced Vascular Morphology Assessment in Choroidal Neovascularization

Published on: August 11, 2023

1.6K
State of the Art Cranial Ultrasound Imaging in Neonates
10:02

State of the Art Cranial Ultrasound Imaging in Neonates

Published on: February 2, 2015

26.3K
Automated Midline Shift and Intracranial Pressure Estimation based on Brain CT Images
14:08

Automated Midline Shift and Intracranial Pressure Estimation based on Brain CT Images

Published on: April 13, 2013

43.7K

Area of Science:

  • Dermatology
  • Gerontology
  • Vascular Biology

Background:

  • Midline capillary formation nuchae (MCFN) presents as pink macules on the occiput and nape.
  • MCFN has been suggested as a potential risk factor for angiosarcoma, possibly linked to reduced capillary innervation.
  • Existing literature on MCFN prevalence is limited in the elderly population.

Purpose of the Study:

  • To determine the prevalence of MCFN in older adults.
  • To investigate if MCFN is a risk factor for angiosarcoma.
  • To explore potential links between MCFN and systemic neuroendocrine effects or local reactions.

Main Methods:

  • Routine skin screening examinations were performed on 411 patients.
  • Prevalence data was analyzed in relation to age, sex, and neuroendocrine markers.

Main Results:

  • MCFN prevalence significantly increased with age (P<.0001), overall and in men (P=.0013).
  • No significant age-related prevalence difference was found in women (P=.0688).
  • No association was observed with parameters influenced by the systemic neuroendocrine system.

Conclusions:

  • MCFN prevalence rises in old age.
  • MCFN is not identified as a risk factor for angiosarcoma.
  • MCFN may represent a local capillary response to normal age-related neuroendocrine system changes.