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Editorial: Identifying Colonic Motor Dysfunction in Chronic Constipation with High-Resolution Manometry: Pan-Colonic
1Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, USA.
The American Journal of Gastroenterology
|March 9, 2017
Summary
High-resolution manometry revealed frequent pan-colonic pressurizations in healthy individuals and constipated patients. These pressure waves, linked to eating and cholinergic stimulation, offer new insights into colonic motor function.
Area of Science:
- Gastroenterology
- Colorectal Physiology
- Diagnostic Technology
Background:
- Colonic manometry assesses motor dysfunction in chronic constipation.
- High-resolution manometry (HRM) offers improved colonic pressure sensing.
- Previous methods used non-high-resolution catheters.
Purpose of the Study:
- To evaluate colonic pressures using high-resolution manometry (HRM).
- To characterize pan-colonic pressurizations in healthy and constipated individuals.
- To explore the functional consequences of these pressure events.
Main Methods:
- Utilized high-resolution manometry (HRM) catheters with closely spaced sensors.
- Assessed colonic pressures in 17 healthy participants and 10 patients with constipation.
- Analyzed pressure changes after eating and cholinergic stimulation.
Main Results:
- Identified frequent pan-colonic pressurizations in both groups.
- Observed increased frequency of these events after eating and cholinergic stimulation.
- Found reduced frequency in patients with slow-transit constipation.
- Noted association with the desire to pass flatus.
Conclusions:
- Pan-colonic pressurizations are a notable finding in colonic manometry.
- These events may play a role in colonic motility and sensation.
- Further research is needed to clarify their pathogenesis and clinical significance in constipation.
