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Related Experiment Video

Updated: Mar 6, 2026

Comparison of Predictive Performance of Three Lymph Node Staging Systems in Colorectal Signet Ring Cell Carcinoma Based on Machine Learning Model

Comparison of Predictive Performance of Three Lymph Node Staging Systems in Colorectal Signet Ring Cell Carcinoma Based on Machine Learning Model

Published on: April 18, 2025

Lymph node evaluation for colon cancer in routine clinical practice: a population-based study.

J C Del Paggio¹, S Nanji², X Wei¹

¹Division of Cancer Care and Epidemiology, Queen's University Cancer Research Institute.

Current Oncology (Toronto, Ont.)

|March 9, 2017

Summary

This summary is machine-generated.

Evaluating 12 or more lymph nodes (lns) in colon cancer surgery improves patient survival. Increased ln yield was linked to better overall and cancer-specific survival for stages II and III disease.

Keywords:

Colon cancer lymph node yield population studies survival factors

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Published on: January 9, 2026

Area of Science:

Oncology
Surgical Pathology
Cancer Research

Background:

Current guidelines recommend evaluating at least 12 lymph nodes (lns) during colon cancer surgery.
This study investigates lymph node yield and its impact on patient survival in real-world clinical practice.

Purpose of the Study:

To determine the association between lymph node yield and survival outcomes in patients with stage II and III colon cancer.
To identify factors influencing lymph node yield in routine surgical practice.

Main Methods:

Utilized electronic health records linked to the Ontario Cancer Registry for colon cancer patients (2002-2008).
Included a random sample (n=5508) of patients with stage II or III disease.
Employed modified Poisson and Cox regression models to analyze lymph node yield and survival.

Main Results:

Median lymph node yield increased significantly from 11 to 17 nodes between 2002-2008 (p < 0.001).
The proportion of patients with ≥12 lymph nodes evaluated rose from 45% to 86% (p < 0.001).
Lower lymph node yield (<12 nodes) was associated with inferior overall and cancer-specific survival for stages II and III disease.

Conclusions:

Despite increased lymph node yield, lymph node positivity rates remained stable.
Lymph node yield is a significant prognostic factor for survival in stage II and III colon cancer.
The observed association between lymph node yield and survival is unlikely due to stage migration.