Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Local Anesthetics: Common Agents and Their Applications01:23

Local Anesthetics: Common Agents and Their Applications

1.1K
Local anesthetics (LAs) are commonly used for various applications in medical and dental procedures. Some of the common agents used are cocaine, lidocaine, and bupivacaine.
Cocaine is an ester of benzoic acid and methylecgogine. It is used to anesthetize and vasoconstrict locally. Currently, it is used primarily for topical applications. It is beneficial for surgeries on the upper respiratory tract, providing anesthesia and shrinking the mucosa. Cocaine in the form of cocaine hydrochloride is...
1.1K
Local Anesthetics: Clinical Application as Surface, Infiltration, and Conduction Block Anesthesia01:30

Local Anesthetics: Clinical Application as Surface, Infiltration, and Conduction Block Anesthesia

2.4K
Depending on the target organ, local anesthetics (LAs) can be administered via various routes. In surface anesthesia, LAs are applied directly to the surface of the skin or mucous membranes. It is widely used for topical skin numbing before venipuncture or minor surgical procedures. Commonly used surface local anesthetics are lidocaine or benzocaine sprays or creams. Surface anesthesia occurs within 5 minutes and lasts for about 60 minutes. One of the main disadvantages of topical anesthesia is...
2.4K
Local Anesthetics: Clinical Application as Spinal Anesthesia01:11

Local Anesthetics: Clinical Application as Spinal Anesthesia

1.7K
Spinal anesthetics are given during lower abdomen and limb surgeries to block sensory and motor neurons. They are administered in the mid to low lumbar regions, primarily acting on the cauda equina's nerve roots. The blockade level depends on the local anesthetic (LA) concentration. Usually, low LA concentrations are sufficient to block sensory fibers, while only high LA concentrations block motor fibers. Other factors like injection volume and speed, the patient's posture, and the drug...
1.7K
Local Anesthetics: Differential Sensitivity of Nerve Fibers01:24

Local Anesthetics: Differential Sensitivity of Nerve Fibers

1.5K
Local anesthetics (LAs) block the sodium channels of nerve trunks, sensory nerve endings, and neuromuscular junctions. Although LAs can block all kinds of nerves, the sensitivity of nerve fibers differs according to nerve types and structures. LAs are known to block myelinated fibers faster than unmyelinated ones. Also, they block pain or sensory neurons at low concentrations without affecting the motor neurons involved in muscle contractions. This helps relieve labor pain without affecting the...
1.5K
Local Anesthetics: Clinical Application as Epidural Anesthesia01:29

Local Anesthetics: Clinical Application as Epidural Anesthesia

889
Epidural anesthetics are administered in the fat-filled epidural space, the outermost part of the spinal canal. This technique is commonly employed for pain management and anesthesia during lower abdomen and pelvis surgeries or labor and delivery.
Since epidural anesthetics can be infused through an epidural catheter, all types of drugs, including short-acting ones, can be administered. Chloroprocaine and lidocaine are examples of short and long-duration anesthetics, respectively. Bupivacaine...
889
Analgesia and Pain Management01:25

Analgesia and Pain Management

2.5K
Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
2.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Maternal obesity shapes associations between preeclampsia and birthweight in pregnancies exposed to low-dose aspirin.

Frontiers in physiology·2026
Same author

Oxygen-ozone autohaemotherapy in fibromyalgia: safety profile and adverse events. A scoping review.

Clinical and experimental rheumatology·2026
Same author

Therapeutic advances in fibromyalgia: one year in review 2026.

Clinical and experimental rheumatology·2026
Same author

Oxygen-ozone autohaemotherapy in fibromyalgia: oxidative stress, Nrf2 activation, small fibre neuropathy and a critical narrative review of the evidence.

Clinical and experimental rheumatology·2026
Same author

COVID-19 vaccination status during pregnancy and preeclampsia risk: the pandemic-era cohort of the INTERCOVID consortium.

EClinicalMedicine·2026
Same author

Fibromyalgia, Eating Disorders and Rehabilitation: The Nrf2 Link.

Antioxidants (Basel, Switzerland)·2026

Related Experiment Video

Updated: Mar 6, 2026

Subcutaneous Trigeminal Nerve Field Stimulation for Refractory Facial Pain
09:35

Subcutaneous Trigeminal Nerve Field Stimulation for Refractory Facial Pain

Published on: May 10, 2017

19.7K

Topical Treatments for Localized Neuropathic Pain.

Roberto Casale1, Z Symeonidou2,3, M Bartolo4

  • 1Department of High Technology Rehabilitation & Pain Rehabilitation Unit, Habilita Care and Research Hospitals, Via Bologna 1-24040, Zingonia di Ciserano (BG), Italy. robertocasale@habilita.it.

Current Pain and Headache Reports
|March 9, 2017
PubMed
Summary
This summary is machine-generated.

Topical treatments for localized neuropathic pain (LNP) show promise for pain reduction with fewer side effects. However, more rigorous studies are needed to confirm the efficacy of various compounds for LNP management.

Keywords:
Localized neuropathic painTopical amitriptylineTopical baclofenTopical clonidineTopical ketamineTopical lidocaine

More Related Videos

Author Spotlight: Advancements and Challenges in Surgical Treatments for Postamputation Pain
03:26

Author Spotlight: Advancements and Challenges in Surgical Treatments for Postamputation Pain

Published on: March 8, 2024

3.7K
The Sciatic Nerve Cuffing Model of Neuropathic Pain in Mice
07:09

The Sciatic Nerve Cuffing Model of Neuropathic Pain in Mice

Published on: July 16, 2014

49.5K

Related Experiment Videos

Last Updated: Mar 6, 2026

Subcutaneous Trigeminal Nerve Field Stimulation for Refractory Facial Pain
09:35

Subcutaneous Trigeminal Nerve Field Stimulation for Refractory Facial Pain

Published on: May 10, 2017

19.7K
Author Spotlight: Advancements and Challenges in Surgical Treatments for Postamputation Pain
03:26

Author Spotlight: Advancements and Challenges in Surgical Treatments for Postamputation Pain

Published on: March 8, 2024

3.7K
The Sciatic Nerve Cuffing Model of Neuropathic Pain in Mice
07:09

The Sciatic Nerve Cuffing Model of Neuropathic Pain in Mice

Published on: July 16, 2014

49.5K

Area of Science:

  • Neurology
  • Pharmacology
  • Pain Management

Background:

  • Localized neuropathic pain (LNP) syndromes are increasingly managed with topical therapies.
  • These approaches are utilized by both specialists and general practitioners for potential pain reduction.

Purpose of the Study:

  • To review available topical compounds for LNP syndromes.
  • To assess their potential efficacy based on existing literature.

Main Methods:

  • This study is a narrative review of scientific literature.
  • It focuses on compounds tested for topical application in LNP.

Main Results:

  • Various agents including local anesthetics, ketamine, baclofen, capsaicin, NSAIDs, salicylates, antidepressants, and clonidine have been investigated.
  • Few topical treatments for LNP have sufficient evidence for systematic use.
  • Potential benefits include limited systemic side effects and drug interactions, alongside satisfactory efficacy.

Conclusions:

  • Topical treatments offer a promising avenue for managing localized neuropathic pain.
  • Further well-designed studies are essential to refine and establish these treatments.