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Related Concept Videos

Tumor Immunotherapy01:27

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
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Updated: Mar 6, 2026

Positron Emission Tomography Imaging of Cell Trafficking: A Method of Cell Radiolabeling
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Advancing Immune and Cell-Based Therapies Through Imaging.

Vladimir Ponomarev1

  • 1Department of Radiology, Molecular Pharmacology and Chemistry Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, 1275 York Ave Z-2063, Box 501, New York, NY, 10065, USA. ponomarv@mskcc.org.

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This review highlights advances in imaging for cancer immunotherapies. Predictive biomarkers and advanced imaging strategies are crucial for effective patient treatment and improved outcomes.

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Area of Science:

  • Molecular imaging
  • Immunotherapy
  • Cancer research

Background:

  • Immunotherapies encompass diverse strategies to modulate immune responses against cancer.
  • The development of predictive biomarkers is essential to personalize immunotherapy treatments.
  • Lack of biomarkers leads to ineffective treatments, patient disappointment, and increased healthcare costs.

Purpose of the Study:

  • To review current cancer immune and cell-based therapies.
  • To discuss recent imaging strategies for improving immunotherapy outcomes.
  • To emphasize the role of imaging in advancing cellular and immune therapies.

Main Methods:

  • Literature review of cancer immunotherapy strategies.
  • Analysis of recent advances in molecular imaging techniques.
  • Discussion of biomarker identification and validation in immunotherapy.

Main Results:

  • Imaging plays a vital role in monitoring and optimizing immunotherapy.
  • Predictive biomarkers enhance treatment efficacy and patient selection.
  • The Imaging in Cellular and Immune Therapies (ICIT) group fosters collaboration.

Conclusions:

  • Integrating advanced imaging is key to maximizing immunotherapy benefits.
  • Biomarker-driven immunotherapy improves patient outcomes and reduces healthcare burden.
  • Continued research in imaging and biomarkers will advance cancer treatment.