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Statins anticancer targeted delivery systems: re-purposing an old molecule
Sally Safwat1, Rania A Ishak1, Rania M Hathout1
1Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Ain Shams University, Abbassia, Cairo, Egypt.
The Journal of Pharmacy and Pharmacology
|March 9, 2017
Summary
Statins show promise as anticancer agents. Encapsulating them in nanoparticles enhances their cancer-fighting ability and targets tumors effectively, reducing side effects.
Area of Science:
- Oncology
- Pharmacology
- Nanotechnology
Background:
- Statins, traditionally used for high cholesterol, exhibit significant anticancer properties.
- Cancer cells often develop resistance to conventional chemotherapy.
Purpose of the Study:
- To review the anticancer potential of statins.
- To explore pharmaceutical strategies for targeted statin delivery in cancer treatment.
Main Methods:
- Literature review of studies on statins in cancer therapy.
- Investigation of nanoparticulate drug delivery systems for statins.
Main Results:
- Statins demonstrate broad-spectrum anticancer activities.
- Nanoparticulate statin delivery enhances cytotoxicity and overcomes drug resistance.
- Targeted nanoparticles allow for reduced drug dosage and improved efficacy.
Conclusions:
- Incorporating statins into nanoparticles is a promising strategy for cancer treatment.
- This approach effectively targets cancer cells, inhibits proliferation, and minimizes side effects compared to traditional chemotherapy.
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