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Could NAMPT inhibition become a potential treatment option in hepatocellular carcinoma?

Antje Garten1,2, Susanne Schuster3,2, Melanie Penke2

  • 1a Institute of Metabolism and Systems Research, College of Medical and Dental Sciences , University of Birmingham , Birmingham , UK.

Expert Review of Anticancer Therapy
|March 9, 2017
PubMed
Abstract

No abstract available in PubMed .

Keywords:
APO866CHS-828FK866GMX1778HepatocarcinomaNADSorafenibnicotinamide phosphoribosyltransferaseresistancesirtuin

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Phase II biotransformation reactions are essential for detoxifying and eliminating xenobiotics, including many pharmaceutical compounds. These reactions typically involve conjugation, the covalent attachment of polar endogenous groups such as glucuronic acid, sulfate, methyl, or acetyl moieties to functional groups introduced during Phase I metabolism. The resulting conjugates are more water-soluble, enabling efficient renal or biliary excretion.The major classes of Phase II enzymes include...
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