Injectable and biodegradable temperature-responsive mixed polymer systems providing variable gel-forming pH regions.
Yasuyuki Yoshida1,2, Keisuke Kawahara1, Shintaro Mitsumune1
1a Faculty of Chemistry, Materials and Bioengineering, Department of Chemistry and Materials Engineering , Kansai University , Suita , Japan.
Journal of Biomaterials Science. Polymer Edition
|March 9, 2017
Summary
Researchers developed novel injectable polymers (IPs) that transition from liquid to gel. These biodegradable polymers offer tunable gelation pH, enhancing their potential for biomedical applications.
Area of Science:
- Biomaterials Science
- Polymer Chemistry
- Drug Delivery Systems
Background:
- Injectable polymers (IPs) are crucial for minimally invasive biomedical applications.
- Stimuli-responsive polymers offer tunable properties for advanced therapies.
- Biodegradable polymers are essential for safe and effective in-vivo applications.
Purpose of the Study:
- To develop novel biodegradable, temperature-responsive injectable polymer systems.
- To create systems with tunable gel-forming pH regions.
- To investigate the sol-to-gel transition behavior of mixed copolymers.
Main Methods:
- Synthesis of PCGA-b-PEG-b-PCGA (tri-PCG) copolymers with terminal carboxylic acid (tri-PCG-COOH) or primary amine (tri-PCG-NH2) groups.
- Preparation of mixed systems of tri-PCG-COOH and tri-PCG-NH2 copolymers.
- Investigation of temperature-responsive sol-to-gel transition behavior at various pH levels.
Main Results:
- The synthesized copolymers exhibited temperature-responsive sol-to-gel transitions.
- The gel-forming pH region of the mixed polymer system was successfully controlled.
- Tunability was achieved by simply altering the mixing ratios of the two copolymers.
Conclusions:
- Novel biodegradable, temperature-responsive injectable polymer systems were successfully developed.
- The gel-forming pH of these systems can be easily modulated by adjusting copolymer mixing ratios.
- These findings support the potential of these tunable IPs for diverse biomedical applications.
Keywords:
Injectable polymerbiodegradablehydrogelpH-responsivesol-to-gel transitiontemperature-responsiveMore Related Videos
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