Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Plasma norepinephrine pharmacokinetics during mental challenge.

D S Goldstein1, G Eisenhofer, F L Sax

  • 1Hypertension-Endocrine Branch, National Heart, Lung, and Blood Institute, Bethesda, MD 20892.

Psychosomatic Medicine
|November 1, 1987
PubMed
Summary

Mental challenge increases norepinephrine (NE) release and alters blood flow, impacting cardiovascular responses. Measuring total body NE pharmacokinetics accurately reflects sympathetic activity during stress.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cardiac sympathetic denervation without Lewy bodies in a case of multiple system atrophy.

Parkinsonism & related disorders·2014
Same author

Stress, allostatic load, catecholamines, and other neurotransmitters in neurodegenerative diseases.

Endocrine regulations·2011
Same author

Catechols in post-mortem brain of patients with Parkinson disease.

European journal of neurology·2010
Same author

Neurocirculatory and nigrostriatal abnormalities in Parkinson disease from LRRK2 mutation.

Neurology·2007
Same author

Cardiovascular aspects of Parkinson disease.

Journal of neural transmission. Supplementum·2006
Same author

Glucagon does not affect catecholamine release in primary cultures of bovine adrenal chromaffin cells.

Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme·2005

Area of Science:

  • Cardiovascular Physiology
  • Neuropharmacology
  • Stress Response

Background:

  • Norepinephrine (NE) is a key neurotransmitter in the sympathetic nervous system.
  • Understanding NE pharmacokinetics is crucial for assessing sympathetic activity.
  • Mental stress can significantly influence cardiovascular and neurochemical parameters.

Purpose of the Study:

  • To investigate the pharmacokinetics of norepinephrine (NE) in the forearm and total body.
  • To evaluate the impact of mental challenge on NE release and hemodynamic responses.
  • To determine the relationship between NE pharmacokinetics, blood flow, and cardiac output.

Main Methods:

  • Intravenous infusion of tracer-labeled norepinephrine (NE) and isoproterenol (ISO) in 14 subjects.

Related Experiment Videos

  • Measurement of NE pharmacokinetics at rest and during mental challenge (video game or cognitive task).
  • Assessment of hemodynamic parameters including heart rate, blood pressure, cardiac output, and forearm blood flow.

    • Main Results:

    • Mental challenge significantly increased heart rate, systolic blood pressure, cardiac output, forearm blood flow, and total body NE spillover.
    • Forearm NE extraction was inversely related to forearm blood flow.
    • Total body NE clearance positively correlated with cardiac output.
    • Changes in antecubital venous NE did not accurately reflect sympathetic nerve activity during mental challenge.

    Conclusions:

    • Mental challenge stimulates sympathetically-mediated NE release, driving hemodynamic changes.
    • Regional variations in sympathetic activity and blood flow complicate the interpretation of peripheral NE levels.
    • Measuring total body and regional NE pharmacokinetics provides a more accurate assessment of sympathetic nerve activity during psychological stress.