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Updated: Mar 6, 2026

Synthesis of Core-shell Lanthanide-doped Upconversion Nanocrystals for Cellular Applications

Synthesis of Core-shell Lanthanide-doped Upconversion Nanocrystals for Cellular Applications

Published on: November 10, 2017

Nanostructures for NIR light-controlled therapies.

Yanmei Yang¹, Junxin Aw², Bengang Xing³

¹Center for Molecular Imaging and Nuclear Medicine, School for Radiological and Interdisciplinary Sciences (RAD-X) and Collaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education Institutions, Soochow University, Suzhou, China 215123. Bengang@ntu.edu.sg.

|March 9, 2017

Summary

This summary is machine-generated.

Precision medicine aims to target disease cells without harming healthy tissue. Near-infrared (NIR) light offers a promising solution for precise phototherapy, overcoming limitations of UV and visible light.

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Area of Science:

Biomedical Engineering
Nanotechnology
Photomedicine

Background:

Precision medicine requires targeted cellular perturbation with minimal damage to healthy tissues.
Light-controlled therapies offer spatiotemporal precision but face challenges with UV/visible light penetration and phototoxicity.
Near-infrared (NIR) light presents a viable alternative due to its deeper tissue penetration and reduced cytotoxicity.

Purpose of the Study:

To provide an overview of therapeutic applications utilizing NIR light-absorbed nanostructures.
To discuss NIR light-controlled drug delivery, photothermal therapy, and photodynamic therapy.
To explore challenges and future prospects in NIR-based phototherapeutics.

Main Methods:

Review of existing literature on NIR light-mediated nanostructures for therapeutic applications.
Analysis of NIR light's advantages over shorter wavelengths for in vitro and in vivo treatments.
Discussion of specific applications including drug delivery, photothermal, and photodynamic therapies.

Main Results:

NIR light enables precise therapeutic interventions with enhanced tissue penetration.
NIR light-activated nanostructures facilitate targeted drug delivery and energy conversion for therapy.
Established applications include NIR-controlled drug release, photothermal ablation, and photodynamic therapy.

Conclusions:

NIR light-based nanostructures are effective for precision phototherapy, overcoming limitations of conventional methods.
Further research into challenges and prospects will advance NIR phototherapeutics for clinical applications.
NIR light offers a safer and more effective modality for advanced medical treatments.