Multiple Pigmented Seborrheic Keratosis with Sebaceous Differentiation - A Case Report

Area of Science:

• Dermatopathology
• Oncology

Background:

• Seborrheic keratosis is a common benign epidermal tumor.
• Histological variants of seborrheic keratosis exist, but sebaceous differentiation is exceptionally rare.
• Sebaceous differentiation can lead to confusion with neoplasms of sebaceous glands.

Observation:

• A 65-year-old male presented with multiple nodules on the neck and preauricular region.
• Histopathological examination revealed multiple pigmented seborrheic keratoses.
• These lesions demonstrated significant sebaceous differentiation.

Findings:

• The case highlights a rare occurrence of seborrheic keratosis with sebaceous differentiation.
• The multiplicity of lesions and sebaceous features presented a diagnostic challenge.
• Histology confirmed benign seborrheic keratosis despite sebaceous elements.

Implications:

• Accurate differentiation from benign and malignant sebaceous neoplasms is crucial.
• Awareness of this rare variant aids in correct diagnosis and patient management.
• This case underscores the importance of thorough histopathological evaluation for skin lesions.