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The study of the relationship between aberrant expression of hot shock protein 70 (HSP70) and spontaneous abortion
1Medical College of Nanchang University, Nanchang, Jiangxi, P.R. China. huai_liu1@163.com.
Objective:
The present study is aimed to explore the relationship between aberrant expression of heat shock protein 70 (HSP) and spontaneous abortion.
Patients And Methods:
50 patients with spontaneous abortion and 50 patients with induced abortion were continuously selected based on the nearest matching principle, and the proportion of age and gestational age was 1:1. The decidual tissues were obtained, and the cell apoptosis was determined by TUNEL assay. Further, the expression of HSP70 was assayed by immune-histochemical staining, and the expression of HSP70 mRNA was detected by the RT-PCR approach.
Results:
Apoptosis rate, HSP70 expression and HSP70 mRNA expression in the observation group were significantly higher than the control group.
Conclusions:
HSP70 might induce apoptosis so as to cause spontaneous abortion.
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