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[Digitalis receptor].

H G Rey1, B M Anner

  • 1Département de pharmacologie, Centre médical universitaire, Genéve.

Schweizerische Medizinische Wochenschrift
|November 28, 1987
PubMed
Summary
This summary is machine-generated.

Cardiac glycosides interact with the Na+,K+-ATPase. Endogenous digoxin-like factors can interfere with radioimmunoassays (RIA) used to monitor patients on these drugs, necessitating careful consideration.

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Area of Science:

  • Pharmacology
  • Biochemistry
  • Clinical Chemistry

Background:

  • The Na+,K+-ATPase is the established pharmacological receptor for cardiac glycosides.
  • Endogenous digoxin-like factors are known to interfere with radioimmunoassays (RIA).
  • Steroid cardiotonics possess a narrow therapeutic range, making monitoring crucial.

Purpose of the Study:

  • To review the digitalis receptor.
  • To discuss RIA monitoring of patients treated with cardiac glycosides.
  • To detail the origin and nature of endogenous digoxin-like factors.

Main Methods:

  • Literature review on cardiac glycoside pharmacology and RIA.
  • Analysis of studies investigating endogenous digoxin-like substances.
  • Discussion of clinical implications for patient monitoring.

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Main Results:

  • The Na+,K+-ATPase serves as the primary target for cardiac glycosides.
  • Endogenous digoxin-like factors can lead to inaccurate RIA results.
  • Understanding these factors is vital for therapeutic drug monitoring.

Conclusions:

  • Accurate monitoring of cardiac glycoside therapy requires accounting for endogenous digoxin-like factors.
  • Further research into the origin and chemical properties of these factors is warranted.
  • RIA methods must be validated to mitigate interference from endogenous substances.