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Author Spotlight: Analyzing Bone Marrow Microenvironment in Murine Hematological Malignancies
Published on: November 10, 2023
[Pathogenesis and genetic landscape of acute myeloid leukemia]
Hajnalka Rajnai1, Attila Péter Király1
1I. Sz. Patológiai és Kísérleti Rákkutató Intézet, Semmelweis Egyetem, Budapest, Hungary. rajnai.hajnalka@med.semmelweis-univ.hu.
Abstract:
The recent advances in the field of molecular biology have enabled a more comprehensive genomic analysis in myeloid malignancies. The studies have unveiled recurrent somatic mutations in several genes illuminating the clinical heterogeneity of these diseases. In this review, we discuss the pathogenesis of de novo and secondary acute myeloid leukemia (AML) in view of recent findings. Mutational analysis of several genes are already included in the everyday diagnostic procedure of AML. The identification of these mutations enables improvements in risk-stratification strategies and provides new potential targets for treatment of AML.
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