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Updated: Mar 6, 2026

An Ex vivo Assay to Study Candida albicans Hyphal Morphogenesis in the Gastrointestinal Tract
Published on: July 1, 2020
[Invasive fungal infections in patients with haematological malignancies]
1Hematológiai és Õssejt-transzplantációs Osztály, Egyesített Szent István és Szent László Kórház, Budapest, Hungary. janos.sinko@istvankorhaz.hu.
Abstract:
Invasive fungal diseases represent an ever changing field within infectology, profoundly affecting daily clinical activities of specialists in haematology. The dynamic development seen in oncohaematology creates novel risk groups of patients, consequently necessitating a re-evaluation of principles in antifungal therapy from time to time. Not even in 2017 may achievements of fungal diagnostics and therapy become a substitute for clinical thinking and adaptation of general guidelines according to local experience. For antifungal management all centres should elaborate appropriate strategies. By creating and operating a multidisciplinary team, decision making can effectively be supported.
Insights
Managing invasive fungal diseases in hematology patients requires adapting strategies. A multidisciplinary team approach is crucial for effective antifungal therapy decisions.
Area of Science:
- Infectious Diseases
- Hematology
- Mycology
Background:
- Invasive fungal diseases (IFDs) pose a significant challenge in clinical infectology, impacting hematology specialists.
- Advancements in oncohematology create evolving patient risk profiles, necessitating periodic reassessment of antifungal therapy guidelines.
Purpose of the Study:
- To emphasize the need for tailored antifungal management strategies in hematology.
- To highlight the importance of integrating clinical judgment with diagnostic and therapeutic advancements.
Main Methods:
- Review of current challenges in IFD management within hematology.
- Discussion on the role of clinical expertise and local adaptation of guidelines.
- Emphasis on the formation of multidisciplinary teams.
Main Results:
- Current achievements in fungal diagnostics and therapy do not replace the need for clinical thinking.
- General guidelines require adaptation based on local institutional experience.
- Multidisciplinary team collaboration can effectively support decision-making in antifungal management.
Conclusions:
- Hematology centers must develop specific strategies for antifungal management.
- Clinical adaptation and local experience are vital for effective IFD treatment.
- Multidisciplinary teams are essential for optimizing patient care in invasive fungal infections.
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