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Evaluation of the associations between childhood asthma and prenatal and perinatal factors

Maryam Kashanian1, Seyyedeh Samaneh Mohtashami1, Mohammad Hassan Bemanian2

  • 1Department of Obstetrics and Gynecology, Iran University of Medical Sciences, Akbarabadi Teaching Hospital, Tehran, Iran.

International Journal of Gynaecology and Obstetrics: the Official Organ of the International Federation of Gynaecology and Obstetrics
|March 9, 2017
PubMed

Insights

Maternal asthma history, pregnancy complications like bleeding, prenatal antibiotic use, and older maternal age increase childhood asthma risk. Breastfeeding offers protection against childhood asthma development.

Area of Science:

  • Pediatrics
  • Epidemiology
  • Environmental Health

Background:

  • Childhood asthma is a significant public health concern.
  • Identifying prenatal and perinatal risk factors is crucial for prevention strategies.

Purpose of the Study:

  • To investigate prenatal and perinatal risk factors associated with childhood asthma.
  • To determine the influence of maternal and pregnancy-related factors on asthma development in children.

Main Methods:

  • A retrospective case-control study involving 134 asthmatic children and 134 controls aged 7-14 years in Tehran, Iran.
  • Data on prenatal and perinatal exposures were collected via maternal questionnaires.
  • Forward logistic regression analysis was employed to identify risk factors.

Main Results:

  • Maternal history of asthma (aOR 11.62) was the strongest predictor.
  • Vaginal bleeding during pregnancy (aOR 3.76), prenatal antibiotic exposure (aOR 3.19), and maternal age ≥30 years (aOR 2.54) were significant risk factors.
  • Breastfeeding demonstrated a protective effect (aOR 0.29).

Conclusions:

  • Maternal asthma history is the most influential factor for childhood asthma.
  • Prenatal exposures, including vaginal bleeding and antibiotic use, along with advanced maternal age, contribute to asthma risk.
  • Breastfeeding is a key protective factor against childhood asthma.
Abstract

Keywords:
AsthmaChildhoodMaternal factorsNeonatePerinatal factorsPregnancyPrematurityPrenatal factors

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