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Updated: May 2, 2026

Millifluidics for Chemical Synthesis and Time-resolved Mechanistic Studies
Published on: November 27, 2013
Networking Nanoswitches for ON/OFF Control of Catalysis
Nikita Mittal1, Susnata Pramanik1, Indrajit Paul1
1Center of Micro and Nanochemistry and Engineering, Organische Chemie I, Universität Siegen , Adolf-Reichwein Straße 2, 57068 Siegen, Germany.
Abstract:
The nanoswitches 1 and 2 are interdependently linked in so-called network states (NetStates). In NetState I, defined by presence of [Cu(1)]+ and 2, the organocatalyst N-methylpyrrolidine catalyzes a conjugate addition. Addition of iron(II) ions as an external chemical trigger to NetState I discharges Cu+ from [Cu(1)]+. The liberated copper(I) ion acts as a second messenger and changes the toggling state at nanoswitch 2. The resulting nanoswitch [Cu(2)]+ captures the catalytically active species from solution and the conjugate addition is turned OFF. Removal of the original trigger reverses the sequence and turns catalysis ON. The ON/OFF catalytic cycle was run three times in situ.
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