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Determination of the Relative Cell Surface and Total Expression of Recombinant Ion Channels Using Flow Cytometry
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Canonical Transient Receptor Potential Channels and Their Link with Cardio/Cerebro-Vascular Diseases

Xiong Xiao1, Hui-Xia Liu1,2, Kuo Shen2

  • 1Department of Pharmacology, School of Pharmacy, Fourth Military Medical University, Xi'an 710032, China.

Biomolecules & Therapeutics
|March 10, 2017
PubMed

Insights

Canonical transient receptor potential channels (TRPCs) are crucial for cell functions and implicated in cardiovascular and cerebrovascular diseases. Targeting TRPCs offers potential therapeutic strategies for these conditions.

Area of Science:

  • Physiology
  • Molecular Biology
  • Cardiovascular Research

Background:

  • Canonical transient receptor potential channels (TRPCs) are nonselective cation channels with diverse roles in cellular functions.
  • Mammalian TRPCs comprise seven members (TRPC1-7), categorized into four subtypes.
  • These channels are integral to essential cellular processes including contraction, relaxation, and proliferation.

Purpose of the Study:

  • To review the current understanding of TRPC involvement in the pathogenesis of cardio/cerebrovascular diseases.
  • To explore the therapeutic potential of TRPCs as drug targets for human cardiovascular and cerebrovascular conditions.

Main Methods:

  • Systematic review of existing literature on TRPCs and cardio/cerebrovascular diseases.
  • Analysis of TRPC roles in specific conditions such as hypertension, cardiac hypertrophy, and ischemia reperfusion injury.

Main Results:

  • TRPCs play a significant role in the pathogenesis of various cardio/cerebrovascular diseases.
  • Specific TRPC subtypes are implicated in hypertension, pulmonary arterial hypertension, cardiac hypertrophy, atherosclerosis, arrhythmia, and cerebrovascular ischemia reperfusion injury.

Conclusions:

  • TRPCs are critical regulators of cardiovascular and cerebrovascular function.
  • TRPCs represent a promising class of drug targets for treating human cardio/cerebrovascular diseases due to their physiological importance.
Keywords:
Ca2+ signalingCanonical transient receptor potential receptorCardiovascular diseaseCerebrovascular diseasePathogenesis

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