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Updated: Mar 6, 2026

Formulation and Characterization of Bioactive Agent Containing Nanodisks
Published on: March 17, 2023
Oral bioavailability enhancement of flubendazole by developing nanofibrous solid dosage forms
Tamás Vigh1, Balázs Démuth1, Attila Balogh1
1a Department of Organic Chemistry and Technology , Budapest University of Technology and Economics , Budapest , Hungary.
Developing amorphous electrospun nanofibres significantly enhanced flubendazole bioavailability. This breakthrough offers potential against tropical diseases like river blindness and elephantiasis.
Area of Science:
- Pharmaceutical Sciences
- Materials Science
Background:
- Flubendazole is an anthelminthic drug with poor bioavailability in its crystalline form.
- Tropical diseases like river blindness and elephantiasis affect over 100 million people globally.
- Enhanced drug delivery systems are needed to improve treatment efficacy.
Purpose of the Study:
- To enhance the bioavailability of the anthelminthic flubendazole.
- To develop amorphous electrospun nanofibres for improved drug dissolution and release.
- To create a formulation potentially effective against macrofilariae parasites.
Main Methods:
- Fabrication of amorphous electrospun nanofibres using hydroxypropyl-β-cyclodextrin and polyvinylpyrrolidone matrix.
- Characterization of nanofibre properties, including dissolution and grindability.
- In vivo pharmacokinetic studies in rats to assess plasma concentration profiles.
Main Results:
- Remarkable enhancement in flubendazole bioavailability compared to the crystalline drug.
- Achieved rapid release of a 40 mg dose within 15 minutes.
- Demonstrated increased plasma concentration in rats with the nanofibrous system.
- Developed easily grindable fibres suitable for immediate-release tablet compression.
Conclusions:
- Amorphous electrospun nanofibres significantly improve flubendazole bioavailability through enhanced dissolution.
- The developed formulation shows promise for treating tropical diseases caused by macrofilariae.
- This technology enables the creation of easily administrable, immediate-release flubendazole tablets.
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