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Related Experiment Video

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The Multiple Sclerosis Performance Test MSPT: An iPad-Based Disability Assessment Tool
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The Performance Scales disability measure for multiple sclerosis: use and sensitivity to clinically important

Carolyn E Schwartz1,2, Victoria E Powell3

  • 1DeltaQuest Foundation, Inc., 31 Mitchell Road, Concord, MA, 01742, USA. carolyn.schwartz@deltaquest.org.

Health and Quality of Life Outcomes
|March 10, 2017
PubMed
Summary

The Performance Scales© is a validated tool for assessing multiple sclerosis (MS) disability. It shows sensitivity to differences in disease trajectory and age, aiding MS clinical research.

Keywords:
Clinical trials outcomesDisabilityEpidemiological researchInterpretationMultiple sclerosisPatient-reported outcomesPerformance ScalesQuality of lifeRehabilitationResponsivenessReview

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Area of Science:

  • Neurology
  • Rehabilitation Medicine
  • Psychometrics

Background:

  • The Performance Scales© was developed in 1993 to evaluate multi-dimensional disability in multiple sclerosis (MS).
  • It has been widely adopted internationally across diverse clinical settings and research designs.
  • This review examines the history, psychometric properties, and application of the Performance Scales©.

Purpose of the Study:

  • To provide a comprehensive overview of the Performance Scales©.
  • To review its psychometric characteristics and international usage over 20 years.
  • To summarize its responsiveness to variations across patient subgroups.

Main Methods:

  • A systematic literature search was conducted using Google Scholar and Ovid.
  • 82 empirical studies utilizing the Performance Scales© were identified from 230 citing articles.
  • Effect sizes were calculated for 12 studies, analyzed by demographics, disease trajectory, and treatment adherence using forest plots.

Main Results:

  • The Performance Scales© demonstrated sensitivity to clinically significant differences related to MS disease trajectory and patient age.
  • Effect sizes were smaller for subgroups based on adherence to disease-modifying therapies and ethnicity.
  • The tool's psychometric soundness supports its utility in clinical research.

Conclusions:

  • The Performance Scales© is a psychometrically validated and widely recognized tool for multiple sclerosis research.
  • Its extensive use highlights its value in characterizing the impact of MS.
  • Future research should utilize the complete measure to capture the whole-person impact of MS.