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Related Concept Videos

Accessory Structures of the Skin: Sebaceous Glands01:21

Accessory Structures of the Skin: Sebaceous Glands

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A sebaceous gland is a type of oil gland found almost all over the skin ( except palms and soles) and helps lubricate and waterproof the skin and hair. Most sebaceous glands are associated with hair follicles. They generate and excrete sebum, a mixture of lipids, onto the skin surface, thereby naturally lubricating the dry and dead layer of keratinized cells of the stratum corneum, keeping it pliable.
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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
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Sexually transmitted infections (STIs) are diseases transmitted primarily through unsafe sexual interactions. Bacteria, viruses, or parasites cause them and can result in severe health complications if untreated.ChlamydiaThe bacterium Chlamydia trachomatis is responsible for the disease Chlamydia, the most common STI in the United States. This peculiar pathogen requires human cells to reproduce, residing intracellularly. The initial infection often goes unnoticed because it typically does not...
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At the molecular level, visual signals trigger transformations in photopigment molecules, resulting in changes in the photoreceptor cell's membrane potential. The photon's energy level is denoted by its wavelength, with each specific wavelength of visible light associated with a distinct color. The spectral range of visible light, classified as electromagnetic radiation, spans from 380 to 720 nm. Electromagnetic radiation wavelengths exceeding 720 nm fall under the infrared category,...
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Dermis
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Author Spotlight: Development and Evaluation of a Compound Acne Rodent Model Using C. acnes and Oleic Acid
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Difficult and rare forms of acne.

Clio Dessinioti1, Andreas Katsambas1

  • 1Department of Dermatology, Andreas Syggros Hospital, University of Athens, 5, Dragoumi str, 16121, Athens, Greece.

Clinics in Dermatology
|March 10, 2017
PubMed
Summary

Many acne cases are treatable, but some patients present with rare or difficult acne forms. Misdiagnosis can occur if other acne-like skin diseases are not ruled out, complicating treatment.

Area of Science:

  • Dermatology
  • Internal Medicine

Background:

  • Acne vulgaris is a common chronic inflammatory skin disease affecting the pilosebaceous unit.
  • While typically manageable, some acne cases present diagnostic and therapeutic challenges.

Purpose of the Study:

  • To highlight the complexities in diagnosing and managing difficult or rare acne presentations.
  • To differentiate acne from other acneiform diseases that mimic its clinical appearance.

Main Methods:

  • Review of clinical presentations of challenging acne cases.
  • Differential diagnosis considerations for refractory or unusual acneiform eruptions.
  • Identification of rare acne subtypes and associated systemic syndromes.

Main Results:

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  • "Nonresponding acne" may indicate an underlying acneiform disease requiring specific diagnosis.
  • Treatment difficulties can stem from patient adherence, inappropriate therapy, or severe acne types like acne conglobata or acne fulminans.
  • Rare acne forms can be associated with systemic conditions such as SAPHO syndrome, PASH syndrome, PAPA syndrome, or congenital adrenal hyperplasia.

    • Conclusions:

    • Accurate diagnosis is crucial to differentiate acne from mimickers and guide appropriate management.
    • Understanding patient-related, treatment-related, and disease-specific factors is essential for effective acne care.
    • Awareness of rare acne subtypes and their syndromic associations aids in comprehensive patient evaluation and management.