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Hormonal therapies for acne.

Brittany Barros¹, Diane Thiboutot¹

¹Department of Dermatology, College of Medicine, The Pennsylvania State University, Hershey, PA, USA.

Clinics in Dermatology

|March 10, 2017

Summary

Androgens significantly influence acne development and severity. This review outlines diagnostic approaches and hormonal therapies for endocrinopathy-related acne in clinical practice.

Area of Science:

Dermatology and Endocrinology

Background:

Acne vulgaris is a common skin condition with multifactorial causes, where androgens play a crucial role.
Endocrinopathies like PCOS or adrenal disorders can manifest with acne, particularly when accompanied by specific symptoms.

Purpose of the Study:

To provide practical guidelines for physicians on diagnosing and managing hormonally related acne.
To review the role of androgens in acne etiology and the available hormonal therapies.

Main Methods:

Literature review focusing on the etiology of acne, diagnostic markers for endocrinopathies, and hormonal treatment strategies.
Synthesis of current clinical guidelines and research on managing acne with hormonal influences.

Main Results:

Androgen excess is a key factor in acne pathogenesis and severity.

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Specific endocrine disorders require targeted hormonal therapies, including androgen receptor blockers, adrenal androgen suppressors, and ovarian androgen suppressors.

Diagnostic workup involves hormone level testing (testosterone, DHEA, LH, FSH) for suspected endocrinopathies.

Conclusions:

Early identification and management of underlying endocrinopathies are essential for effective acne treatment.
Hormonal therapies offer effective treatment options for acne linked to hormonal imbalances.
Physician awareness and adherence to guidelines are critical for optimal patient outcomes in hormonally related acne.