The effect of metilpheniydate, risperidone and combination therapy on ECG in children with attention-deficit
Derya Karpuz1, Olgu Hallioglu1, Fevziye Toros2
1Mersin University, Faculty of Medicine, Department of Pediatric Cardiology, TR, Mersin, Turkey.
Introduction:
This study is to investigate ventricular repolarization on electrocardiogram (ECG) in a pediatric population receiving methylphenidate (MPH), risperidone (RIS) and combined therapy.
Methods:
A total of 215 patients between 6 and 12years with ADHD/conduct disorder receiving methylphenidate, risperidone and combined therapy for minimum 3months and an untreated ADHD group (n=76) was consecutively included in the study. Twelve lead ECG parameters including mean QT, QTc, T-peak to T-end (TpTe) intervals, TpTe dispersion and TpTe/QT ratio were compared.
Results:
QT interval, and QTc, TpTe interval, TpTe dispersion and TpTe/QTc ratio values for groups receiving RIS, MPH and combined therapy were found to be significantly higher than other groups. Moreover, in the combined therapy group TpTe and TpTe/QTc values were higher than the single drug administration groups (p<0.05). TpTe and TpTe/QT ratio was significantly higher in the RIS group compared to that of the MPH group.
Conclusion:
These results suggested that combined therapy of these drugs had a more prominent impact on the T wave and RIS could be strongly associated with it.
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