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Research considerations in the evaluation of minimally invasive pancreatic resection (MIPR)
Jeffrey Barkun1, William Fisher2, Giana Davidson3
1McGill University Heath Center, McGill University, Montreal, Canada.
Abstract:
The IHPBA/AHPBA-sponsored 2016 minimally invasive pancreatic resection (MIPR) conference held on April 20th, 2016 included a session designed to evaluate what would be the most appropriate scientific contribution to help define the increasing role of MIPR internationally. Participants in the conference reviewed the assessment of numerous pertinent scientific designs including randomized controlled trial (RCT), pragmatic international RCT, registry-RCT, non-RCT with propensity matching, and various types of clinical registries including those aiming to create a quality improvement data system or a learning health care system. The strengths and weaknesses of each of these designs, the status of trials which are currently recruiting patients, and pragmatic considerations were evaluated. A recommendation was made to establish a clinical registry to collect data prospectively from around the world to assess current practices and provide a framework for future studies in MIPR.
Insights
Experts recommend establishing a global clinical registry to track minimally invasive pancreatic resection (MIPR) practices. This registry will provide data for future studies and define MIPR's growing international role.
Area of Science:
- Surgical Oncology
- Gastroenterology
- Medical Informatics
Background:
- The 2016 IHPBA/AHPBA conference convened to determine the optimal scientific approach for defining the expanding role of minimally invasive pancreatic resection (MIPR) globally.
- Discussions evaluated various research designs, including randomized controlled trials (RCTs), pragmatic international RCTs, registry-RCTs, non-RCTs with propensity matching, and diverse clinical registries.
Framework:
- The conference assessed the strengths and weaknesses of each proposed scientific design.
- Current trial recruitment status and pragmatic considerations for international data collection were critically examined.
Implementation:
- A key recommendation was the establishment of a prospective international clinical registry for MIPR.
- This registry aims to collect global data on current surgical practices.
Implications:
- The proposed registry will serve as a foundational framework for future research in minimally invasive pancreatic resection.
- It will facilitate a better understanding of MIPR's current landscape and guide its future development.
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