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A Fluorescence-based Method to Study Bacterial Gene Regulation in Infected Tissues
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A Fluorescence-based Method to Study Bacterial Gene Regulation in Infected Tissues

Published on: February 19, 2019

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Members of a new subgroup of Streptococcus anginosus harbor virulence related genes previously observed in

Anshu Babbar1, Venkatesan Naveen Kumar2, René Bergmann3

  • 1Microbial Interactions and Processes Research Group, Helmholtz Centre for Infection Research, Braunschweig, Germany.

International Journal of Medical Microbiology : IJMM
|March 10, 2017
PubMed

Insights

Streptococcus anginosus, often overlooked pathogens, show potential for new strains with virulence and resistance genes. This discovery impacts diagnosing and treating Streptococcus infections.

Area of Science:

  • Microbiology
  • Genomics
  • Pathogen Discovery

Background:

  • Streptococcus anginosus are facultative human pathogens, often misclassified as commensals.
  • Their diagnosis and understanding of pathogenesis are hindered by taxonomic and molecular complexities.

Purpose of the Study:

  • To investigate the pathogenic potential of S. anginosus isolates.
  • To explore the genetic basis of virulence and antibiotic resistance in S. anginosus.

Main Methods:

  • Multi-locus sequence analysis (MLSA) of S. anginosus isolates from India and Germany.
  • PCR screening for Streptococcus pyogenes virulence factors and antibiotic resistance genes.

Main Results:

  • Identification of a potential new clade, genomosubspecies vellorensis, within S. anginosus.
  • Detection of S. pyogenes-like superantigen and extracellular DNase genes.
  • Presence of erythromycin and tetracycline resistance genes in S. anginosus isolates.

Conclusions:

  • S. anginosus possesses significant pathogenic potential, including novel clades and acquired virulence/resistance genes.
  • These findings highlight challenges in diagnosing and treating S. anginosus infections.
  • Further research is needed to understand the clinical implications of these findings.
Keywords:
Antibiotic resistanceDNaseMLSAStreptococcus anginosusSuperantigenVirulence factor

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